Bridging the gap between microbial limits and extremes in space: space microbial biotechnology in the next 15 years.
Bridging the gap between microbial limits and extremes in space: space microbial biotechnology in the next 15 years.
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DOI：
10.1111/1751-7915.13927
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发表时间：
2022-01
影响因子：
5.7
通讯作者：
Cockell CS
中科院分区：
文献类型：
--
作者：
Cockell CS
在太空建立永久人类住区是人类的雄心壮志之一。为了实现这一目标，微生物将被用于执行许多功能，如回收，食品和药品生产，采矿和其他过程。然而，地球以外所有地方的物理和化学极端条件都超过了微生物生命已知的生长极限。让微生物对更大范围的地外极端环境更加宽容，将不会产生可以在未经改造的地外环境中生长的生物体，因为在其中许多环境中甚至不存在液态水。然而，通过缩小差距，可以降低对生物工业过程的工程要求，并且可以将更大的鲁棒性并入生物组分中。我确定并描述了这些所需的微生物生物技术改造，并推测了长期的可能性，例如土星卫星泰坦上的微生物生物技术，以支持人类在外太阳系的存在和小行星的生物处理。空间微生物生物技术在未来几十年面临的一个挑战是缩小微生物差距，方法是系统地确定完成这一任务所需的基因，并将其纳入可用于进行相关生物工业过程的微生物系统。未来几十年太空微生物生物技术面临的一个挑战是缩小已知生命的生长极限与外星环境中发现的条件之间的微生物差距。
The establishment of a permanent human settlement in space is one of humanity’s ambitions. To achieve this, microorganisms will be used to carry out many functions such as recycling, food and pharmaceutical production, mining and other processes. However, the physical and chemical extremes in all locations beyond Earth exceed known growth limits of microbial life. Making microbes more tolerant of a greater range of extraterrestrial extremes will not produce organisms that can grow in unmodified extraterrestrial environments since in many of them not even liquid water can exist. However, by narrowing the gap, the engineering demands on bioindustrial processes can be reduced and greater robustness can be incorporated into the biological component. I identify and describe these required microbial biotechnological modifications and speculate on long‐term possibilities such as microbial biotechnology on Saturn’s moon Titan to support a human presence in the outer Solar System and bioprocessing of asteroids. A challenge for space microbial biotechnology in the coming decades is to narrow the microbial gap by systemically identifying the genes required to do this and incorporating them into microbial systems that can be used to carry out bioindustrial processes of interest. A challenge for space microbial biotechnology in the coming decades is to narrow the microbial gap between the growth limits of known life and conditions to be found in extraterrestrial environments.
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影响因子：
4.2
作者：
Fajardo-Cavazos, Patricia;Waters, Samantha M.;Nicholson, Wayne L.
通讯作者：
Nicholson, Wayne L.
影响因子：
16.6
作者：
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影响因子：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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Leonetti JP