Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats.
Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats.
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DOI：
10.1038/s41598-017-06220-0
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发表时间：
2017-07-19
影响因子：
4.6
通讯作者：
Caldarelli S
中科院分区：
文献类型：
--
作者：
Tranchida F;Rakotoniaina Z;Shintu L;Tchiakpe L;Deyris V;Yemloul M;Stocker P;Vidal N;Rimet O;Hiol A;Caldarelli S
评估了口服补充姜黄提取物（剂量与人类常用营养相关）对高果糖和饱和脂肪酸（HFS）饮食的大鼠肝脏代谢的影响。高分辨率魔角旋转 NMR 和 GC/MS 与多变量分析相结合，分别用于表征肝组织的 NMR 代谢物谱和脂肪酸组成。结果显示，HFS 组和对照组之间存在明显差异，涉及葡萄糖、糖原、氨基酸、乙酸盐、胆碱、溶血磷脂酰胆碱、磷脂酰乙醇胺和 β-羟基丁酸等代谢物，以及 MUFA 增加和 n-6 和 n-3 PUFA 减少。尽管给予 CL 并不能抵消 HFS 饮食的有害影响，但与单独喂养 HFS 饮食的大鼠相比，接受姜黄提取物的大鼠肝脏样本中的一些代谢物，即一些 n-6 PUFA 和 n-3 PUFA 以及甜菜碱显着增加。该结果表明类姜黄素可能影响转甲基化途径和/或渗透调节。大鼠体内补充 CL 提取物似乎可以通过作用于胆碱代谢来增加肝脏的脂肪输出，从而增强一些预防脂肪肝发展的自然防御能力。
The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs. Although the administration of CL did not counteract deleterious effects of the HFS diet, some metabolites, namely some n-6 PUFA and n-3 PUFA, and betaine were found to increase significantly in liver samples from rats having received extract of curcuma compared to those fed the HFS diet alone. This result suggests that curcuminoids may affect the transmethylation pathway and/or osmotic regulation. CL extract supplementation in rats appears to increase some of the natural defences preventing the development of fatty liver by acting on the choline metabolism to increase fat export from the liver.
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影响因子：
7.1
作者：
Brosnan, Margaret E.;Brosnan, John T.
通讯作者：
Brosnan, John T.
影响因子：
7.1
作者：
Grundy, SM
通讯作者：
Grundy, SM
影响因子：
4.3
作者：
Abdullah, Mohammad M.;Riediger, Natalie N.;Moghadasian, Mohammed H.
通讯作者：
Moghadasian, Mohammed H.
影响因子：
5.4
作者：
de Castro GS;Deminice R;Simões-Ambrosio LM;Calder PC;Jordão AA;Vannucchi H
通讯作者：
Vannucchi H
影响因子：
4.5
作者：
Basciano, Heather;Federico, Lisa;Adeli, Khosrow
通讯作者：
Adeli, Khosrow