Effects of heartbeat and respiration on macaque fMRI: implications for functional connectivity.
Effects of heartbeat and respiration on macaque fMRI: implications for functional connectivity.
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DOI：
10.1016/j.neuropsychologia.2009.11.026
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发表时间：
2010-06
期刊：
影响因子：
2.6
通讯作者：
Ferrera VP
中科院分区：
文献类型：
--
作者：
Teichert T;Grinband J;Hirsch J;Ferrera VP
功能性磁共振成像（fMRI）在非人灵长类动物中的应用日益增加。众所周知，血氧水平依赖（BOLD）信号不仅随局部神经元能量消耗而变化，还随心脏和呼吸活动而变化。我们绘制了麻醉猕猴的这些周期性心脏和呼吸伪影，并对它们对功能连接性估计（fcMRI）的影响进行了客观分析。发现存在明显心脏和呼吸伪影的体素所在区域与先前针对清醒人类所报道的区域大致相同。我们展示了两个示例种子，在其中去除伪影明显减少了假阳性和假阴性相关的数量。特别是，去除伪影减少了所谓的静息态网络中的相关性。在某些情况下，时间带通滤波或空间平滑可能有助于减少伪影的影响，但并不能充分替代明确模拟并去除周期性心脏和呼吸伪影的算法。
The use of functional magnetic resonance imaging (fMRI) in non-human primates is on the increase. It is known that the blood-oxygen-level-dependent (BOLD) signal varies not only as a function of local neuronal energy consumption but also as a function of cardiac and respiratory activity. We mapped these cyclic cardiac and respiratory artifacts in anesthetized macaque monkeys and present an objective analysis of their impact on estimates of functional connectivity (fcMRI). Voxels with significant cardiac and respiratory artifacts were found in much the same regions as previously reported for awake humans. We show two example seeds where removing the artifacts clearly decreased the number of false positive and false negative correlations. In particular, removing the artifacts reduced correlations in the so called resting state network. Temporal band-pass filtering or spatial smoothing may help to reduce the effects of artifacts in some cases but are not an adequate replacement for an algorithm that explicitly models and removes cyclic cardiac and respiratory artifacts.
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DOI：
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发表时间：
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影响因子：
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发表时间：
2008-04-08
影响因子：
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