Enhancing the Hydrophobicity and Antibacterial Properties of SiCN-Coated Surfaces with Quaternization to Address Peri-Implantitis.
Enhancing the Hydrophobicity and Antibacterial Properties of SiCN-Coated Surfaces with Quaternization to Address Peri-Implantitis.
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DOI：
10.3390/ma16175751
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发表时间：
2023-08-22
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影响因子：
--
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种植体周围炎是导致种植体失败的主要原因。这种疾病是种植体周围组织的炎症，虽然病因是多因素的，但细菌是引发炎症反应的罪魁祸首。碳氮化硅（SiCN）涂层牙种植体与传统钛种植体相比具有许多潜在的优势，但其抗菌效果尚未得到评估。本研究的目的是通过表面原子的季铵化修饰SiCN涂层植入物的表面，使其氮原子带正电荷，从而确定SiCN的抗菌潜能。通过接触角测量和XPS分析证实了表面化学的变化。将改性SiCN表面接种变形链球菌（S. mutans），并与硅对照进行比较。实验组培养的细菌菌落比对照硅表面少80%。用活菌染色的荧光显微镜显示，在3天和7天后，细菌覆盖率显著降低。利用扫描电子显微镜（SEM）观察细菌接种后的包覆表面，并通过观察表面破裂的细菌膜来证实季铵化SiCN的抗菌作用机制。
Peri-implantitis is a major cause of dental implant failure. This disease is an inflammation of the tissues surrounding the implant, and, while the cause is multi-factorial, bacteria is the main culprit in initiating an inflammatory reaction. Dental implants with silicon carbonitride (SiCN) coatings have several potential advantages over traditional titanium implants, but their antibacterial efficiency has not yet been evaluated. The purpose of this study was to determine the anti-bacterial potential of SiCN by modifying the surface of SiCN-coated implants to have a positive charge on the nitrogen atoms through the quaternization of the surface atoms. The changes in surface chemistry were confirmed using contact angle measurement and XPS analysis. The modified SiCN surfaces were inoculated with Streptococcus mutans (S. mutans) and compared with a silicon control. The cultured bacterial colonies for the experimental group were 80% less than the control silicon surface. Fluorescent microscopy with live bacteria staining demonstrated significantly reduced bacterial coverage after 3 and 7 days of incubation. Scanning electron microscopy (SEM) was used to visualize the coated surfaces after bacterial inoculation, and the mechanism for the antibacterial properties of the quaternized SiCN was confirmed by observing ruptured bacteria membrane along the surface.
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DOI：
10.3390/antibiotics10111350
发表时间：
2021-11-05
期刊：
Antibiotics (Basel, Switzerland)
影响因子：
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作者：
Jennes ME;Naumann M;Peroz S;Beuer F;Schmidt F
通讯作者：
Schmidt F
影响因子：
3.2
作者：
Koo, H.;Xiao, J.;Jeon, J. G.
通讯作者：
Jeon, J. G.
DOI：
10.1007/978-3-319-11038-7_5
发表时间：
2015-01-01
期刊：
BIOFILM-BASED HEALTHCARE-ASSOCIATED INFECTIONS, VOL I
影响因子：
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作者：
Faveri, Marcelo;Figueiredo, Luciene Cristina;Feres, Magda
通讯作者：
Feres, Magda
影响因子：
7.3
作者：
Haldar, J;Kondaiah, P;Bhattacharya, S
通讯作者：
Bhattacharya, S
影响因子：
4.6
作者：
Guan, Yong;Qian, Liying;Xiao, Huining
通讯作者：
Xiao, Huining