Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort.
Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort.
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DOI：
10.1176/appi.ajp.2009.08071068
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Goldman D
中科院分区：
文献类型：
--
作者：
Ducci F;Roy A;Shen PH;Yuan Q;Yuan NP;Hodgkinson CA;Goldman LR;Goldman D
遗传变异会影响人群中对成瘾的不同易感性。然而，目前尚不清楚易感等位基因频率的差异是否会导致人群之间的差异，以及血统在多大程度上与贫困和创伤等环境风险因素的不同暴露相关。作者使用186个血统信息标记来测量407名吸毒者和457名自称非裔美国人的对照受试者的非洲血统。参照组是来自人类基因组多样性细胞系小组的1,051个个体，该小组包括代表全球最大遗传多样性的51个不同群体。非洲裔美国人在非洲、欧洲、中东和中亚的基因遗传程度各不相同。实际上，可卡因、鸦片和酒精成瘾者的非洲血统总体水平(比例=0.76-0.78)低于非成瘾的非裔美国人对照受试者(比例=0.81)。非洲血统与生活在贫困社区有关，这是一个以前与风险相关的因素。非洲血统与儿童时期遭受虐待或忽视之间没有关联，这是一个强烈预测所有类型成瘾的因素。这些结果表明，非洲的遗传遗产不会增加成瘾的遗传风险。它们突出了遗传祖先与社会、经济和环境条件之间的复杂相互关系，以及这些因素与成瘾的密切关系。需要对以遗传血统和社会、心理、人口、经济、文化和历史因素为特征的流行病学样本进行研究，以更好地理清导致人口间成瘾易感性差异和其他健康差异的遗传和环境因素的影响。
Genetic variation influences differential vulnerability to addiction within populations. However, it remains unclear whether differences in frequencies of vulnerability alleles contribute to disparities between populations and to what extent ancestry correlates with differential exposure to environmental risk factors, including poverty and trauma. The authors used 186 ancestry-informative markers to measure African ancestry in 407 addicts and 457 comparison subjects self-identified as African Americans. The reference group was 1,051 individuals from the Human Genome Diversity Cell Line Panel, which includes 51 diverse populations representing most worldwide genetic diversity. African Americans varied in degrees of African, European, Middle Eastern, and Central Asian genetic heritage. The overall level of African ancestry was actually smaller among cocaine, opiate, and alcohol addicts (proportion=0.76–0.78) than nonaddicted African American comparison subjects (proportion=0.81). African ancestry was associated with living in impoverished neighborhoods, a factor previously associated with risk. There was no association between African ancestry and exposure to childhood abuse or neglect, a factor that strongly predicted all types of addictions. These results suggest that African genetic heritage does not increase the likelihood of genetic risk for addictions. They highlight the complex interrelation between genetic ancestry and social, economic, and environmental conditions and the strong relation of those factors to addiction. Studies of epidemiological samples characterized for genetic ancestry and social, psychological, demographic, economic, cultural, and historical factors are needed to better disentangle the effects of genetic and environmental factors underlying interpopulation differences in vulnerability to addiction and other health disparities.
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影响因子：
4.2
作者：
Ensminger, ME;Anthony, JC;McCord, J
通讯作者：
McCord, J
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
DOI：
10.1016/s0899-3289(00)00015-8
发表时间：
2000-01-01
期刊：
JOURNAL OF SUBSTANCE ABUSE
影响因子：
--
作者：
Caetano, R;Cunradi, CB;Schafer, J
通讯作者：
Schafer, J
影响因子：
10.5
作者：
Bulik, CM;Prescott, CA;Kendler, KS
通讯作者：
Kendler, KS
影响因子：
2.8
作者：
Klimentidis, Yann C.;Miller, Geoffrey F.;Shriver, Mark D.
通讯作者：
Shriver, Mark D.