An intestinal zinc sensor regulates food intake and developmental growth.
An intestinal zinc sensor regulates food intake and developmental growth.
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DOI：
10.1038/s41586-020-2111-5
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发表时间：
2020-04
期刊：
影响因子：
64.8
通讯作者：
Miguel-Aliaga I
中科院分区：
文献类型：
--
作者：
Redhai S;Pilgrim C;Gaspar P;Giesen LV;Lopes T;Riabinina O;Grenier T;Milona A;Chanana B;Swadling JB;Wang YF;Dahalan F;Yuan M;Wilsch-Brauninger M;Lin WH;Dennison N;Capriotti P;Lawniczak MKN;Baines RA;Warnecke T;Windbichler N;Leulier F;Bellono NW;Miguel-Aliaga I
在细胞、器官和身体中，营养感测是维持体内平衡和适应波动环境的关键。在许多动物的消化系统中，肠内分泌细胞具有营养传感器;对于它们的细胞兄弟-吸收性肠上皮细胞中的营养传感知之甚少。黑腹果蝇的遗传筛选确定了Hodor：一种肠上皮细胞离子型受体，特别是在营养缺乏的条件下维持幼虫发育。在非洲爪蟾卵母细胞和苍蝇的实验表明，Hodor是一个pH敏感的锌门控氯离子通道，介导了以前未被认识到的饮食偏好锌。Hodor通过促进食物摄入和胰岛素/IGF信号传导来控制肠细胞（间质细胞）亚群的全身生长。虽然Hodor维持肠腔酸度并抑制微生物负荷，但其对全身生长的影响来自于间质细胞内Tor信号传导和溶酶体稳态的调节。Hodor样基因是昆虫特异性的，并且可能代表疾病媒介控制的特异性靶标。事实上，CRISPR/Cas9基因组编辑揭示了冈比亚按蚊hodor直系同源物是一个必需基因。我们的研究结果强调了需要考虑金属和更普遍的微量营养素对能量稳态的指导性贡献。
In cells, organs and bodies, nutrient sensing is key to maintaining homeostasis and adapting to a fluctuating environment. In the digestive system of many animals, enteroendocrine cells harbour nutrient sensors; less is known about nutrient sensing in their cellular siblings – the absorptive enterocytes. A genetic screen in Drosophila melanogaster identified Hodor: an enterocyte ionotropic receptor that sustains larval development particularly in nutrient-scarce conditions. Experiments in Xenopus oocytes and flies indicate that Hodor is a pH-sensitive zinc-gated chloride channel that mediates a previously unrecognised dietary preference for zinc. Hodor controls systemic growth from a subset of enterocytes (interstitial cells) by promoting food intake and insulin/IGF signalling. Although Hodor sustains gut luminal acidity and restrains microbial loads, its effect on systemic growth results from modulation of Tor signalling and lysosomal homeostasis within interstitial cells. Hodor-like genes are insect-specific, and may represent specific targets for disease vector control. Indeed, CRISPR/Cas9 genome editing revealed that the single Anopheles gambiae hodor orthologue is an essential gene. Our findings underscore the need to consider instructive contributions of metals and, more generally, micronutrients to energy homeostasis.
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影响因子：
3.7
作者：
Erkosar B;Defaye A;Bozonnet N;Puthier D;Royet J;Leulier F
通讯作者：
Leulier F
影响因子：
2.8
作者：
Feingold, Daniel;Starc, Tanja;Dent, Joseph A.
通讯作者：
Dent, Joseph A.
影响因子：
14.9
作者：
Kriventseva EV;Kuznetsov D;Tegenfeldt F;Manni M;Dias R;Simão FA;Zdobnov EM
通讯作者：
Zdobnov EM
DOI：
10.3390/v10050225
发表时间：
2018-04-26
期刊：
Viruses
影响因子：
--
作者：
Holly MK;Smith JG
通讯作者：
Smith JG
影响因子：
11.8
作者：
Layalle, Sophie;Arquier, Nathalie;Leopold, Pierre
通讯作者：
Leopold, Pierre