Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B.
Peripheral Immune Cells Exhaustion and Functional Impairment in Patients With Chronic Hepatitis B.
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DOI：
10.3389/fmed.2021.759292
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发表时间：
2021
影响因子：
3.9
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Jin X;Yan ZH;Lu L;Lu S;Zhang G;Lin W
乙肝病毒感染后，病毒在宿主体内引起多种免疫紊乱，导致免疫逃逸，最终导致疾病的慢性化。本研究调查了慢性乙型肝炎(CHB)患者的免疫细胞缺陷和功能损害。我们分析了外周血中不同免疫细胞亚群的百分比、功能、表型以及血浆中细胞因子的浓度。我们比较了慢性乙型病毒性肝炎患者和健康人的结果。结果发现，CHB患者NK细胞和T细胞功能受损，NK细胞和T细胞NKG2A、PD-1等抑制性受体表达增加。功能障碍主要表现为细胞因子的分泌，细胞毒作用未见明显减弱。我们还发现CHB患者树突状细胞(DC)比例降低，调节性B细胞(BREG)比例增加。BREG细胞与T细胞因子呈负相关，与ALT、乙肝病毒载量呈正相关。提示CHB患者外周血免疫细胞功能紊乱，尤其是NK细胞和T细胞功能受损。这些细胞呈耗竭状态，调节性B细胞的增多可能是导致这种现象的原因之一。
After infection of hepatitis B virus (HBV), the virus induces a variety of immune disorders in the host, leading to immune escape and, finally, the chronicity of the disease. This study investigated immune cell defects and functional impairment in patients with chronic hepatitis B (CHB). We analyzed the percentage, function, and phenotypes of various immune cell subpopulations in the peripheral blood along with the concentrations of cytokines in the plasma. We compared the results between patients with CHB and healthy individuals. It was found that in patients with CHB, the cell function was impaired and, there was increased expression of inhibitory receptors, such as NKG2A and PD-1 in both NK and T cells. The impairment of function was mainly in cytokine secretion, and the cytotoxicity was not significantly diminished. We also found that the proportion of dendritic cells (DC) decreased and regulatory B cells (Breg) increased in CHB. In addition, the Breg cells were negatively correlated with T cell cytokine and positively correlated with ALT and HBV viral load. Taken together, various disorders and functional impairments were found in the immune cells of peripheral blood in CHB patients, especially NK and T cells. These cells showed exhaustion and the increase of regulatory B cells may be one of the reasons for this phenomenon.
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影响因子：
6.7
作者：
Peppa D;Micco L;Javaid A;Kennedy PT;Schurich A;Dunn C;Pallant C;Ellis G;Khanna P;Dusheiko G;Gilson RJ;Maini MK
通讯作者：
Maini MK
影响因子：
3.7
作者：
Seeger, Christoph;Mason, William S.
通讯作者：
Mason, William S.
影响因子：
13.5
作者：
Stoop, JN;van der Molen, RG;Janssen, HLA
通讯作者：
Janssen, HLA
慢性病毒肝炎的发病机理：T细胞和NK细胞的差异作用。
影响因子：
82.9
作者：
通讯作者：
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影响因子：
7.3
作者：
Maini MK;Peppa D
通讯作者：
Peppa D