The role of iron in the skin and cutaneous wound healing.
The role of iron in the skin and cutaneous wound healing.
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DOI：
10.3389/fphar.2014.00156
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发表时间：
2014
影响因子：
5.6
通讯作者：
Srai SK
中科院分区：
文献类型：
--
作者：
Wright JA;Richards T;Srai SK
在这篇综述文章中，我们讨论了目前的知识铁在皮肤和皮肤伤口愈合过程。铁在氧化应激和光诱导的皮肤损伤中起着关键作用。皮肤中氧化应激的主要原因包括由紫外线（UVA）光谱的320-400 nm部分在皮肤中产生的活性氧物质（ROS）和生物可利用的铁。我们还讨论了缺铁、贫血和皮肤伤口愈合之间的关系。对此的研究分为两类。早期研究使用各种实验方法研究了贫血对伤口愈合的影响，以确定贫血或缺铁，并侧重于伤口强度，而不是对宏观愈合或上皮再生的影响。最近的动物研究已经调查了旨在纠正全身性铁缺乏和局部铁过载的影响的新治疗方法。铁超载与局部皮肤铁沉积有关，其在慢性静脉疾病和遗传性血色病中具有许多有害作用。铁在慢性溃疡和诸如类风湿性关节炎（RA）和红斑狼疮的病症中起关键作用，所述病症与慢性疾病的贫血和局部皮肤铁止血的失调两者相关。通过应用局部铁螯合剂和新型药理学试剂，铁是皮肤中的潜在治疗靶点，并且通过治疗铁缺乏或潜在的全身性炎症，铁是延迟皮肤伤口愈合的潜在治疗靶点。
In this review article we discuss current knowledge about iron in the skin and the cutaneous wound healing process. Iron plays a key role in both oxidative stress and photo-induced skin damage. The main causes of oxidative stress in the skin include reactive oxygen species (ROS) generated in the skin by ultraviolet (UVA) 320–400 nm portion of the UVA spectrum and biologically available iron. We also discuss the relationships between iron deficiency, anemia and cutaneous wound healing. Studies looking at this fall into two distinct groups. Early studies investigated the effect of anemia on wound healing using a variety of experimental methodology to establish anemia or iron deficiency and focused on wound-strength rather than effect on macroscopic healing or re-epithelialization. More recent animal studies have investigated novel treatments aimed at correcting the effects of systemic iron deficiency and localized iron overload. Iron overload is associated with local cutaneous iron deposition, which has numerous deleterious effects in chronic venous disease and hereditary hemochromatosis. Iron plays a key role in chronic ulceration and conditions such as rheumatoid arthritis (RA) and Lupus Erythematosus are associated with both anemia of chronic disease and dysregulation of local cutaneous iron hemostasis. Iron is a potential therapeutic target in the skin by application of topical iron chelators and novel pharmacological agents, and in delayed cutaneous wound healing by treatment of iron deficiency or underlying systemic inflammation.
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影响因子：
4.1
作者：
Farberg, Aaron S.;Jing, Xi L.;Monson, Laura A.;Donneys, Alexis;Tchanque-Fossuo, Catherine N.;Deshpande, Sagar S.;Buchman, Steven R.
通讯作者：
Buchman, Steven R.
影响因子：
4.9
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影响因子：
2.4
作者：
LOBE, TE;RICHARDSON, CJ;ONEILL, J
通讯作者：
ONEILL, J
DOI：
10.1111/j.1600-0781.2011.00604.x
发表时间：
2011-10-01
影响因子：
2.6
作者：
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通讯作者：
Huang, Xi
影响因子：
9
作者：
BAINS, JW;CRAWFORD, DT;KETCHAM, AS
通讯作者：
KETCHAM, AS