Therapeutic intraspinal stimulation to generate activity and promote long-term recovery.
Therapeutic intraspinal stimulation to generate activity and promote long-term recovery.
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DOI：
10.3389/fnins.2014.00021
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发表时间：
2014
影响因子：
4.3
通讯作者：
Moritz CT
中科院分区：
文献类型：
--
作者：
Mondello SE;Kasten MR;Horner PJ;Moritz CT
神经修复方法通过在其他紊乱的回路中诱导适当的神经活动，在治疗脑和脊髓损伤方面具有巨大的潜力。大量的工作已经证明，对中枢和外周神经系统施加刺激会在损伤后立即产生益处，并且在某些情况下会产生持续的益处。在这里，我们专注于颈部椎管内微刺激（ISMS）作为一种有前途的方法，激活脊髓远端的损伤部位，直接产生运动或更有趣的是，以改善随后的意志控制的瘫痪肢体。在人类患者中最常见的是脊髓的不完全损伤，这些损伤使神经组织绕过可能受到神经装置影响的病变，以促进功能恢复。事实上，最近的结果表明，治疗ISMS导致不完全脊髓损伤（SCI）后前肢功能的适度但持续的改善。这种治疗性脊髓刺激可以通过提供神经元存活、轴突生长和突触稳定性所需的必要电活动来促进功能的长期恢复。
Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system leads to immediate and in some cases sustained benefits after injury. Here we focus on cervical intraspinal microstimulation (ISMS) as a promising method of activating the spinal cord distal to an injury site, either to directly produce movements or more intriguingly to improve subsequent volitional control of the paretic extremities. Incomplete injuries to the spinal cord are the most commonly observed in human patients, and these injuries spare neural tissue bypassing the lesion that could be influenced by neural devices to promote recovery of function. In fact, recent results have demonstrated that therapeutic ISMS leads to modest but sustained improvements in forelimb function after an incomplete spinal cord injury (SCI). This therapeutic spinal stimulation may promote long-term recovery of function by providing the necessary electrical activity needed for neuron survival, axon growth, and synaptic stability.
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影响因子：
5.3
作者：
Brushart, TM;Jari, R;Gordon, T
通讯作者：
Gordon, T
影响因子：
5.3
作者：
Brus-Ramer, Marcel;Carmel, Jason B.;Martin, John H.
通讯作者：
Martin, John H.
影响因子：
14
作者：
Bamford, Jeremy A.;Todd, Kathryn G.;Mushahwar, Vivian K.
通讯作者：
Mushahwar, Vivian K.
影响因子：
6.3
作者：
COX, SB;WOOLSEY, TA;ROVAINEN, CM
通讯作者：
ROVAINEN, CM
DOI：
10.1523/jneurosci.1435-10.2010
发表时间：
2010-08-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Carmel JB;Berrol LJ;Brus-Ramer M;Martin JH
通讯作者：
Martin JH