Season of birth is associated with adult body mass index in patients with bipolar disorder.
Season of birth is associated with adult body mass index in patients with bipolar disorder.
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DOI：
10.3109/07420528.2012.754452
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发表时间：
2013-05
影响因子：
2.8
通讯作者：
Kupfer DJ
中科院分区：
文献类型：
--
作者：
Soreca I;Cheng Y;Frank E;Fagiolini A;Kupfer DJ
心血管危险因素，如腹部肥胖和一般肥胖，在双相情感障碍（BD）患者中非常普遍。虽然长期使用精神药物是这些风险因素的重要决定因素，但其他证据表明，早期发展可能与情绪障碍素质相互作用，以指数方式增加肥胖的风险。本研究的目的是检验双相情感障碍患者的出生季节是否与成人体重指数（BMI）和腹部肥胖相关。我们比较了出生季节对375例成人双相情感障碍患者和196例成人单相抑郁症患者BMI的影响。我们发现出生季节对双相情感障碍患者的BMI有显着影响，但对单相情感障碍患者的BMI没有影响。在双相情感障碍患者中，出生季节也与腰围有关，男性的影响更大。出生季节影响双相情感障碍患者的成年BMI和腰围，但对单相抑郁症患者没有影响。我们的研究结果表明，早期的环境因素，尚未确定，与双相情感障碍的特定神经生物学特征，以确定稳定的性状和疾病的危险因素在成年后的生活。
Cardiovascular risk factors, such as abdominal obesity and obesity in general, are very prevalent among patients with bipolar disorder (BD). Although long-term use of psychotropic medications is an important determinant of these risk factors, other evidence suggests that early development may interact with the mood disorder diathesis to exponentially increase the risk of obesity. The goal of our study was to test whether season of birth is associated with adult body mass index (BMI) and abdominal obesity in individuals with bipolar disorder. We compared season of birth effects on BMI in 375 adult patients with bipolar disorder and 196 adult patients with unipolar major depression. We found a significant season of birth effect on BMI in patients with bipolar disorder, but not unipolar. In patients with bipolar disorder, season of birth was also associated with waist circumference, with a stronger effect in males. Season of birth affects adult BMI and waist circumference in patients with bipolar disorder, but not in patients with unipolar depression. Our results suggest that early environmental factors, yet to be identified, interact with specific neurobiological features of bipolar disorder to determine stable traits and disease risk factors in adult life.
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