The other white-nose syndrome transcriptome: Tolerant and susceptible hosts respond differently to the pathogen Pseudogymnoascus destructans.
The other white-nose syndrome transcriptome: Tolerant and susceptible hosts respond differently to the pathogen Pseudogymnoascus destructans.
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DOI：
10.1002/ece3.3234
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发表时间：
2017-09
影响因子：
2.6
通讯作者：
Kyle CJ
中科院分区：
文献类型：
--
作者：
Davy CM;Donaldson ME;Willis CKR;Saville BJ;McGuire LP;Mayberry H;Wilcox A;Wibbelt G;Misra V;Bollinger T;Kyle CJ
缓解威胁全球生物多样性的新发传染病需要了解宿主和病原体对感染的关键反应。对于多宿主病原体，其中病原体毒力或宿主易感性是可变的，耐受性物种中的宿主-病原体相互作用可能确定最近暴露的易感宿主的适应性进化的潜在途径。例如，真菌Pseudogymnoascus destructans会在冬眠的蝙蝠中引起白鼻综合征（WNS），并导致北美一些物种的灾难性减少，该真菌最近被引入北美。在欧洲和亚洲，这种病原体是地方性的，蝙蝠只受到轻微的影响。新北极和古北极冬眠动物之间不同的环境条件被认为是导致不同疾病结果的原因，但这一假设尚未得到实验验证。我们首次报道了一种欧洲蝙蝠（大鼠耳蝙蝠，Myotis Myotis）对P. destructans反应的对照实验研究。我们比较了治疗后在受控环境条件下冬眠的对照组（假暴露组）和暴露组肌支气管炎患者的身体状况、疾病结局和基因表达。耐受性肌支气管炎的真菌生长极为有限，没有表现出WNS症状。然而，我们在暴露的蝙蝠中没有检测到与免疫反应相关的基因的差异表达，这表明免疫反应并不驱动在冬眠后期对破坏性单胞菌的耐受性。不同种类蝙蝠对毁灭单胞虫的不同反应不能仅仅归因于环境或生态因素。相反，我们的结果暗示了与病原体的共同进化，并强调了“白鼻综合征转录组”的动态性质。宿主（也可能是病原体）暴露后的种间变异强调了蝙蝠- WNS系统研究中环境的重要性，在尝试使用特定蝙蝠物种作为可推广的“模型宿主”之前，应先对不同宿主和病原体暴露后的遗传反应进行强有力的表征。
Mitigation of emerging infectious diseases that threaten global biodiversity requires an understanding of critical host and pathogen responses to infection. For multihost pathogens where pathogen virulence or host susceptibility is variable, host–pathogen interactions in tolerant species may identify potential avenues for adaptive evolution in recently exposed, susceptible hosts. For example, the fungus Pseudogymnoascus destructans causes white‐nose syndrome (WNS) in hibernating bats and is responsible for catastrophic declines in some species in North America, where it was recently introduced. Bats in Europe and Asia, where the pathogen is endemic, are only mildly affected. Different environmental conditions among Nearctic and Palearctic hibernacula have been proposed as an explanation for variable disease outcomes, but this hypothesis has not been experimentally tested. We report the first controlled, experimental investigation of response to P. destructans in a tolerant, European species of bat (the greater mouse‐eared bat, Myotis myotis). We compared body condition, disease outcomes and gene expression in control (sham‐exposed) and exposed M. myotis that hibernated under controlled environmental conditions following treatment. Tolerant M. myotis experienced extremely limited fungal growth and did not exhibit symptoms of WNS. However, we detected no differential expression of genes associated with immune response in exposed bats, indicating that immune response does not drive tolerance of P. destructans in late hibernation. Variable responses to P. destructans among bat species cannot be attributed solely to environmental or ecological factors. Instead, our results implicate coevolution with the pathogen, and highlight the dynamic nature of the “white‐nose syndrome transcriptome.” Interspecific variation in response to exposure by the host (and possibly pathogen) emphasizes the importance of context in studies of the bat‐WNS system, and robust characterization of genetic responses to exposure in various hosts and the pathogen should precede any attempts to use particular bat species as generalizable “model hosts.”
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影响因子：
2.6
作者：
James TY;Toledo LF;Rödder D;da Silva Leite D;Belasen AM;Betancourt-Román CM;Jenkinson TS;Soto-Azat C;Lambertini C;Longo AV;Ruggeri J;Collins JP;Burrowes PA;Lips KR;Zamudio KR;Longcore JE
通讯作者：
Longcore JE
DOI：
10.1098/rspb.2015.2861
发表时间：
2016-03-16
影响因子：
4.7
作者：
Hoyt, Joseph R.;Langwig, Kate E.;Kilpatrick, A. Marm
通讯作者：
Kilpatrick, A. Marm
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
14.9
作者：
Cunningham F;Amode MR;Barrell D;Beal K;Billis K;Brent S;Carvalho-Silva D;Clapham P;Coates G;Fitzgerald S;Gil L;Girón CG;Gordon L;Hourlier T;Hunt SE;Janacek SH;Johnson N;Juettemann T;Kähäri AK;Keenan S;Martin FJ;Maurel T;McLaren W;Murphy DN;Nag R;Overduin B;Parker A;Patricio M;Perry E;Pignatelli M;Riat HS;Sheppard D;Taylor K;Thormann A;Vullo A;Wilder SP;Zadissa A;Aken BL;Birney E;Harrow J;Kinsella R;Muffato M;Ruffier M;Searle SM;Spudich G;Trevanion SJ;Yates A;Zerbino DR;Flicek P
通讯作者：
Flicek P
影响因子：
3.7
作者：
Hoyt JR;Cheng TL;Langwig KE;Hee MM;Frick WF;Kilpatrick AM
通讯作者：
Kilpatrick AM