Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection.
Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection.
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DOI：
10.1371/journal.pone.0026840
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Sata M
中科院分区：
文献类型：
--
作者：
Sumie S;Kawaguchi T;Kuromatsu R;Takata A;Nakano M;Satani M;Yamada S;Niizeki T;Torimura T;Sata M
脂联素被证明与各种癌症的发展和进展呈负相关。我们评估了脂联素水平是否与丙型肝炎病毒（HCV）感染患者中肝细胞癌（HCC）和肝纤维化的患病率和组织学分级相关。对97例HCC患者（病例）和97例HCV感染患者的性别、Child-Pugh分级和血小板计数进行了病例对照研究。血清总脂联素和高分子量（HMW）脂联素水平通过酶联免疫吸附测定法测定，并检查其与HCC患病率的关系。此外，这些脂联素水平与体重指数（BMI），肝纤维化的进展，和HCC的组织学分级之间的关系也进行了评估。采用天冬氨酸转氨酶与血小板比率指数（APRI）评估肝纤维化。血清总脂联素和高分子量脂联素水平在病例组和对照组之间无显著性差异。此外，在病例组和对照组中，血清总脂联素和高分子量脂联素水平与BMI之间均无负相关。血清总脂联素和高分子量脂联素水平与APRI呈正相关（分别为r= 0.491，P<0.001和r =0.485，P<0.001），与对照组呈正相关（分别为r= 0.482，P<0.001和r =0.476，P<0.001）。 血清总脂联素（OR 11.76，95% CI：2.97-46.66 [P<0.001]）和高分子量脂联素（OR 10.24，CI：2.80-37.40 [P<0.001]）水平降低是HCC组织学分级变差的独立危险因素。我们的研究结果表明，血清总脂联素和高分子量脂联素水平是肝纤维化的预测因子，但不是HCV感染患者肝癌患病率的预测因子。此外，这些脂联素水平低与较差的组织学分级显著相关。
Adiponectin is shown to be inversely associated with development and progression of various cancers. We evaluated whether adiponectin level was associated with the prevalence and histological grade of hepatocellular carcinoma (HCC), and liver fibrosis in patients with hepatitis C virus (HCV) infection. A case-control study was conducted on 97 HCC patients (cases) and 97 patients (controls) matched for sex, Child-Pugh grade and platelet count in patients with HCV infection. The serum total and high molecular weight (HMW) adiponectin levels were measured by enzyme-linked immunosorbent assays and examined in their association with the prevalence of HCC. In addition, the relationship between these adiponectin levels and body mass index (BMI), progression of liver fibrosis, and histological grade of HCC was also evaluated. Liver fibrosis was assessed using the aspartate aminotransferase to platelet ratio index (APRI). There were no significant differences in the serum total and HMW adiponectin levels between cases and controls. Moreover, there were no inverse associations between serum total and HMW adiponectin levels and BMI in both cases and controls. On the other hand, serum total and HMW adiponectin levels are positively correlated with APRI in both cases (r = 0.491, P<0.001 and r = 0.485, P<0.001, respectively) and controls (r = 0.482, P<0.001 and r = 0.476, P<0.001, respectively). Interestingly, lower serum total (OR 11.76, 95% CI: 2.97–46.66 [P<0.001]) and HMW (OR 10.24, CI: 2.80–37.40 [P<0.001] adiponectin levels were independent risk factors of worse histological grade of HCC. Our results suggested that serum total and HMW adiponectin levels were predictors of liver fibrosis, but not prevalence of HCC in patients with HCV infection. Moreover, low these adiponectin levels were significantly associated with worse histological grades.
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