The crosstalk between viral RNA- and DNA-sensing mechanisms.
The crosstalk between viral RNA- and DNA-sensing mechanisms.
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DOI：
10.1007/s00018-021-04001-7
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Zheng C
中科院分区：
文献类型：
--
作者：
Cai C;Tang YD;Xu G;Zheng C
病毒感染通过引起许多传染性甚至致命的疾病对人类构成严重威胁，例如2019年以来的当前大流行疾病（COVID-19），了解宿主先天免疫系统如何识别病毒变得更加重要。内体和细胞质传感器可以检测病毒核酸诱导I型干扰素和促炎细胞因子，进而诱导干扰素刺激基因限制病毒感染。虽然病毒的RNA和DNA传感通常依赖于不同的受体和接头，但DNA和RNA传感之间的串扰逐渐被认识到。这篇综述强调了抗病毒先天免疫中RNA和dna传感机制之间的重叠，这一机制显著增强了抗病毒先天反应以限制病毒感染，可能是预防和治疗病毒性疾病的潜在新靶点。
Viral infections pose a severe threat to humans by causing many infectious, even fatal, diseases, such as the current pandemic disease (COVID-19) since 2019, and understanding how the host innate immune system recognizes viruses has become more important. Endosomal and cytosolic sensors can detect viral nucleic acids to induce type I interferon and proinflammatory cytokines, subsequently inducing interferon-stimulated genes for restricting viral infection. Although viral RNA and DNA sensing generally rely on diverse receptors and adaptors, the crosstalk between DNA and RNA sensing is gradually appreciated. This minireview highlights the overlap between the RNA- and DNA-sensing mechanisms in antiviral innate immunity, which significantly amplifies the antiviral innate responses to restrict viral infection and might be a potential novel target for preventing and treating viral diseases.
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