Volitional determinants and age-related decline in fecundability: a general population prospective cohort study in Denmark.
Volitional determinants and age-related decline in fecundability: a general population prospective cohort study in Denmark.
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自愿决定因素和与年龄相关的繁殖力下降：丹麦的一项普通人群前瞻性研究。
DOI：
10.1016/j.fertnstert.2013.02.040
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发表时间：
2013-06
影响因子：
6.7
通讯作者：
Hatch EE
中科院分区：
文献类型：
--
作者：
Rothman KJ;Wise LA;Sørensen HT;Riis AH;Mikkelsen EM;Hatch EE
量化生育能力随年龄的自然下降，并评估选定的意志因素的影响。试图怀孕妇女的前瞻性队列研究。年龄在20-40岁的丹麦妇女一般人群队列。2820名未患不孕症的妇女，在研究开始时试图怀孕少于3个周期。没有。受孕率。年龄对生育能力几乎没有影响，除了35-40岁的女性，与20-24岁的女性相比，年龄对生育能力的影响为0.77。男性的年龄也出现了类似但较小的下降，35-39岁的男性降至0.95。年龄对生育和未生育妇女的影响不同，后者在20岁时相对于生育能力经历了更大的年龄相关下降。性交频率、使用非激素避孕作为最后一种方法和性交时间对生育能力的影响都很小。在这三种意志因素中处于高生育能力类别的妇女估计怀孕的概率为88% （95% CI: 83%-93%）。与年龄不同，这些因素代表了个人的选择，它们一起可以抵消一些与年龄有关的生育能力下降。生育能力在30岁左右达到顶峰，未生育的女性比有生育的女性稍早，然后下降。随着年龄的增长，男性的下降幅度较小。夫妻双方各自的年龄相关衰退将会带来复杂的影响。在40岁时，一对夫妇的生育能力大约是30岁时的一半，但这种下降可以通过影响受孕的意志因素来抵消。
To quantify the natural decline in fecundability by age and assess the effect of selected volitional factors. Prospective cohort study of women attempting conception. General population cohort of Danish women aged 20–40 years. 2,820 women without infertility, trying to conceive for less than 3 cycles at study entry. none. fecundability. Age had little effect on fecundability except for women 35–40 yrs, for whom it was 0.77 relative to women aged 20–24. Male age showed a similar but smaller drop, declining to 0.95 for men aged 35–39. The effect of age differed for parous and nulliparous women, with the latter experiencing much stronger age-related declines relative to fecundability at age 20. Frequency of intercourse, use of nonhormonal birth control as the last method, and timing of intercourse each had small effects on fecundability. Women who were in the high-fecundability categories for all three of these volitional factors had an estimated probability of conceiving of 88% (95% CI: 83%–93%). Unlike age, these factors represent individual choices that together can offset some of the age-related decline in fecundability. Fecundability peaks around age 30, slightly earlier for nulliparous than for parous women, and then declines. The decline with age is more modest for males. Couples will experience a compounded effect of their separate age-related declines. At age 40, a couple’s fecundability would be approximately half of what it is at age 30, but some of this decline can be counteracted by volitional factors affecting conception.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
5
作者：
Jensen, TK;Scheike, T;Grandjean, P
通讯作者：
Grandjean, P
影响因子：
158.5
作者：
SCHWARTZ, D;MAYAUX, MJ
通讯作者：
MAYAUX, MJ
影响因子：
6.7
作者：
Hassan, MAM;Killick, SR
通讯作者：
Killick, SR
影响因子：
105.7
作者：
HOWE, G;WESTHOFF, C;YEATES, D
通讯作者：
YEATES, D