Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes.
Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes.
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DOI：
10.3390/ijerph13111103
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发表时间：
2016-11-08
影响因子：
--
通讯作者：
Drosdzol-Cop A
中科院分区：
文献类型：
--
作者：
Bąk E;Marcisz C;Kadłubowska M;Michalik A;Krawczyk B;Dobrzyń-Matusiak D;Krzemińska S;Fiałkowski T;Glądys E;Drosdzol-Cop A
外周动脉疾病（PAD）是一种与老年相关的常见病。踝臂指数（ABI）是判断PAD严重程度的一个简单工具。本研究的目的是确定老年伴有和不伴有糖尿病的阻塞性PAD疾病（PAOD）患者ABI变化的独立因素。研究对象为49例老年pad患者，其中2型糖尿病患者29例，非糖尿病患者20例。测定血清中白细胞介素-6 （IL-6）、e -选择素、纤维蛋白原、c反应蛋白（CRP）的浓度。所有患者均采用多元logistic回归分析确定影响ABI变化的独立因素。我们的结果显示，在合并糖尿病的PAD患者组中，ABI与年龄、PAD症状持续时间、BMI、低密度脂蛋白胆固醇、纤维蛋白原、性别相关（决定系数R2 = 0.699）。无糖尿病的PAD患者ABI与年龄、PAD症状持续时间、CRP、e -选择素、高密度脂蛋白胆固醇水平、肾小球滤过率相关（决定系数R2 = 0.844）。我们得出结论，在伴有和不伴有糖尿病的老年pad患者中，与ABI相关的独立因素的参与是多样化的；糖尿病患者IL-6、纤维蛋白原浓度低于非糖尿病患者，e -选择素浓度高于非糖尿病患者。
Peripheral arterial disease (PAD) belongs to the commonly-occurring pathologies associated with elderly age. A simple tool for defining the severity of PAD is the ankle-brachial index (ABI). The purpose of this research was to determine independent factors of changes of ABI in elderly patients with occlusive PAD disease (PAOD) with and without diabetes. The research was carried out on 49 elderly patients with PAOD, including 29 patients with type 2 diabetes, and 20 patients without diabetes. The concentration of interleukin-6 (IL-6), E-selectin, fibrinogen, and C-reactive protein (CRP) in the blood serum was marked. In all patients, the independent factors of changes of ABI were determined with the use of the multiple logistic regression analysis. Our results show that in the group of patients with PAOD suffering from diabetes, it was demonstrated that the ABI was related to age, the duration of the symptoms of PAD, body mass index (BMI), low-density lipoprotein cholesterol, fibrinogen, and sex (determination coefficient R2 = 0.699). In patients with PAOD without diabetes, the ABI was related to age, the duration of the symptoms of PAD, the levels of CRP, E-selectin, high-density lipoprotein cholesterol, and the glomerular filtration rate(determination coefficient R2 = 0.844). We conclude that in elderly patients with PAOD with and without diabetes, the participation of independent factors related to the ABI is diversified; in patients with diabetes, the concentration of IL-6 and fibrinogen is lower, and the concentration of E-selectin is higher than in patients without diabetes.
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影响因子：
0.2
作者：
Thwaswini, K. O.;Roopakala, M. S.;Kumar, Prasanna K. M.
通讯作者：
Kumar, Prasanna K. M.
影响因子：
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通讯作者：
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通讯作者：
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