Facile synthetic route for surface-functionalized magnetic nanoparticles: cell labeling and magnetic resonance imaging studies.
Facile synthetic route for surface-functionalized magnetic nanoparticles: cell labeling and magnetic resonance imaging studies.
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DOI：
10.1021/nn201198f
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发表时间：
2011-06-28
期刊：
影响因子：
17.1
通讯作者：
Park TG
中科院分区：
文献类型：
--
作者：
Chung HJ;Lee H;Bae KH;Lee Y;Park J;Cho SW;Hwang JY;Park H;Langer R;Anderson D;Park TG
由于潜在的聚集、超顺磁性的降低和有毒试剂的使用，目前可用的将氧化铁纳米颗粒（IONP）稳定分散在水溶液中的方法需要改进。在此，我们提出了一种简单的策略，用于水转移和分散的有机合成的IONP仅使用聚乙二醇（PEG），生物相容性聚合物。筛选PEG衍生物的库，并且确定胺官能化的六臂PEG 6（PEG-NH 2）是最有效的分散剂。6（PEG-NH 2）-修饰的离子纳米粒子（IONP-6PEG）经大量洗涤后稳定，表现出高的超顺磁性，可作为生物活性聚合物二次表面功能化的平台材料。透明质酸生物功能化的IONP-6PEG（IONP-6PEG-HA）显示出特异性标记间充质干细胞，并显示出与市售的菲立磁（182.1 s-1 mM-1）相比具有高r2弛豫率（442.7 s-1 mM-1）的MR对比潜力。
Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH2), was the most effective dispersion agent. The 6(PEG-NH2)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r2 relaxivity (442.7 s−1mM−1) compared to the commercially available Feridex (182.1 s−1mM−1).
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