Rift valley fever outbreak in Sembabule District, Uganda, December 2020.
Rift valley fever outbreak in Sembabule District, Uganda, December 2020.
复制标题
DOI：
10.1186/s42522-023-00092-3
复制
发表时间：
2023-11-27
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
裂谷热是一种病毒性人畜共患疾病，可导致人类严重出血热和牲畜高死亡率和流产。2020年12月10日，乌干达卫生部接到通知，一名25岁的男性在乌干达病毒研究所通过逆转录聚合酶链反应（RT-PCR）检测出RV F阳性后死亡。我们进行了调查，以确定爆发的范围，确定暴露因素，并制定控制措施。疑似病例为2020年11月1日至12月31日Semabule区一名居民的急性发热（或腋温> 37.5 ℃）和头痛、肌肉或关节疼痛、意外出血和任何胃肠炎症状中的≥ 2项。1例确诊病例是通过RT-PCR检测裂谷热病毒核酸或通过酶联免疫吸附试验（ELISA）检测血清IgM抗体。疑似动物病例是有任何流产史的牲畜（牛、绵羊、山羊）。经确认的动物病例是通过ELISA检测到抗裂谷热IgM抗体。我们从与指示病例一起工作的牧民那里采集了血液样本进行裂谷热检测，并进行了访谈，以了解更多关于暴露和临床特征的信息。我们审查了医疗记录，并进行了积极的社区搜索，以确定其他嫌疑人。从指示病例农场和两个邻近农场的动物身上采集了血样，用于裂谷热检测。指示病例经常饮用生牛奶。与他一起工作的7名牧民和他兄弟的妻子都没有出现症状;但是，一名牧民的血液样本抗裂谷热特异性IgM和IgG呈阳性。指示病例和额外的确诊病例患者均未宰杀或屠宰任何病/死动物，也未处理流产动物;然而，其他一些牧民报告了接触动物体液和饮用生奶的高风险。在采集的55份动物样本（2只雄性和53只雌性）中，29份（53%）抗裂谷热IgG呈阳性。2020年12月，Semabule县发生了两起人类裂谷热病例，可能是由受感染的牛与人之间的密切互动引起的。在全区范围内开展动物血清调查、动物疫苗接种和社区感染预防实践教育运动，可使人们了解裂谷热的风险，减少疾病负担。在线版本包含补充材料，可通过10.1186/s42522-023-00092-3获得。
Rift Valley Fever (RVF) is a viral zoonosis that can cause severe haemorrhagic fevers in humans and high mortality rates and abortions in livestock. On 10 December 2020, the Uganda Ministry of Health was notified of the death of a 25-year-old male who tested RVF-positive by reverse-transcription polymerase chain reaction (RT-PCR) at the Uganda Virus Research Institute. We investigated to determine the scope of the outbreak, identify exposure factors, and institute control measures. A suspected case was acute-onset fever (or axillary temperature > 37.5 °C) and ≥ 2 of: headache, muscle or joint pain, unexpected bleeding, and any gastroenteritis symptom in a resident of Sembabule District from 1 November to 31 December 2020. A confirmed case was the detection of RVF virus nucleic acid by RT-PCR or serum IgM antibodies detected by enzyme-linked immunosorbent assay (ELISA). A suspected animal case was livestock (cattle, sheep, goats) with any history of abortion. A confirmed animal case was the detection of anti-RVF IgM antibodies by ELISA. We took blood samples from herdsmen who worked with the index case for RVF testing and conducted interviews to understand more about exposures and clinical characteristics. We reviewed medical records and conducted an active community search to identify additional suspects. Blood samples from animals on the index case’s farm and two neighbouring farms were taken for RVF testing. The index case regularly drank raw cow milk. None of the seven herdsmen who worked with him nor his brother’s wife had symptoms; however, a blood sample from one herdsman was positive for anti-RVF-specific IgM and IgG. Neither the index case nor the additional confirmed case-patient slaughtered or butchered any sick/dead animals nor handled abortus; however, some of the other herdsmen did report high-risk exposures to animal body fluids and drinking raw milk. Among 55 animal samples collected (2 males and 53 females), 29 (53%) were positive for anti-RVF-IgG. Two human RVF cases occurred in Sembabule District during December 2020, likely caused by close interaction between infected cattle and humans. A district-wide animal serosurvey, animal vaccination, and community education on infection prevention practices campaign could inform RVF exposures and reduce disease burden. The online version contains supplementary material available at 10.1186/s42522-023-00092-3.
登录
查看更多内容
DOI：
10.1073/pnas.2004468117
发表时间：
2020-09-29
影响因子：
11.1
作者：
Métras R;Edmunds WJ;Youssouffi C;Dommergues L;Fournié G;Camacho A;Funk S;Cardinale E;Le Godais G;Combo S;Filleul L;Youssouf H;Subiros M
通讯作者：
Subiros M
影响因子：
1.7
作者：
Hartman, Amy
通讯作者：
Hartman, Amy
影响因子：
6.4
作者：
Ksiazek, TG;Rollin, PE;Peters, CJ
通讯作者：
Peters, CJ
影响因子：
5.4
作者：
Bird, Brian H.;Githinji, Jane W. K.;Nichol, Stuart T.
通讯作者：
Nichol, Stuart T.
影响因子：
1.4
作者：
Austin, Kelly F.;Bellinger, Megan O.;Rana, Priyokti
通讯作者：
Rana, Priyokti