Alzheimer Disease and Its Growing Epidemic: Risk Factors, Biomarkers, and the Urgent Need for Therapeutics.
Alzheimer Disease and Its Growing Epidemic: Risk Factors, Biomarkers, and the Urgent Need for Therapeutics.
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DOI：
10.1016/j.ncl.2016.06.009
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发表时间：
2016-11
影响因子：
2.4
通讯作者：
Wisniewski, Thomas
中科院分区：
文献类型：
--
作者：
Hickman, Richard A.;Faustin, Arline;Wisniewski, Thomas
Alzheimer disease represents one of the greatest medical challenges that face this century; the condition is becoming increasingly prevalent worldwide and as yet, no effective treatments have been developed for this terminal disease. Since the disease manifests at a late stage after a long period of clinically silent neurodegeneration, knowledge of the modifiable risk factors and the implementation of biomarkers is crucial in the primary prevention of the disease and pre-symptomatic detection of AD, respectively. This review discusses the growing epidemic of AD and antecedent risk factors in the disease process. Disease biomarkers are discussed and the implications that this may have for the treatment of this currently incurable disease.
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DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
1.7
作者：
Cribbs, DH;Chen, LS;LaFerla, FM
通讯作者：
LaFerla, FM
影响因子：
4.2
作者：
Brier, Matthew R.;McCarthy, John E.;Vlassenko, Andrei G.
通讯作者：
Vlassenko, Andrei G.
影响因子：
34.7
作者：
Bu, Guojun
通讯作者：
Bu, Guojun