Reproducible microbiome composition signatures of anxiety and depressive symptoms.
Reproducible microbiome composition signatures of anxiety and depressive symptoms.
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可重复的微生物组组成的焦虑和抑郁症状的特征。
DOI：
10.1016/j.csbj.2023.10.035
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发表时间：
2023
影响因子：
6
通讯作者：
中科院分区：
文献类型：
--
作者：
肠道微生物组对心理健康有重要贡献，越来越多的证据表明其组成与焦虑和抑郁症有关。肠道微生物组的组成与临床诊断的情绪障碍和一般人群的亚临床焦虑和抑郁症状相关，并且可能受到膳食纤维摄入量和慢性疼痛的影响。我们通过回顾现有的研究，提供了关于肠道微生物组组成在抑郁症和焦虑症或症状中的作用的最新证据。通过分析三个独立队列（骨关节炎 1 (OA1)；n = 46、骨关节炎 2 (OA2)；n = 58 和健康对照 (CON)；n = 67）的数据，我们确定了属水平上焦虑和抑郁症状的微生物组成特征，并通过对我们的结果与之前发表的研究结果进行荟萃分析，交叉验证了我们的发现。双歧杆菌属（固定效应β（95% CI）= −0.22（−0.34，−0.10），p = 3.90e-04）和毛螺菌科NK4A136组（固定效应β（95% CI）= −0.09（−0.13，−0.05），p = 2.53e-06）被发现在我们的三个队列和已发表的文献中，考虑到人口和生活方式的协变量（例如纤维摄入量），分别是焦虑和抑郁症状的最佳预测因子。与焦虑的相关性在解释队列之间的异质性方面是强有力的，并支持之前关于双歧杆菌对焦虑症状的潜在预防作用的观察。焦虑和抑郁的症状与肠道微生物群有关。五种细菌属与焦虑和抑郁症状有关。两个慢性疼痛组的关联性比对照组更强。一项荟萃分析发现双歧杆菌与较低的焦虑症状相关。我们的结果与补充益生菌减少焦虑的观察结果一致。
The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diagnosed mood disorders and subclinically in the general population and may be influenced by dietary fibre intake and the presence of chronic pain. We provide an update of current evidence on the role of gut microbiome composition in depressive and anxiety disorders or symptoms by reviewing available studies. Analysing data from three independent cohorts (osteoarthritis 1 (OA1); n = 46, osteoarthritis 2 (OA2); n = 58, and healthy controls (CON); n = 67), we identified microbial composition signatures of anxiety and depressive symptoms at genus level and cross-validated our findings performing meta-analyses of our results with results from previously published studies. The genera Bifidobacterium (fixed-effect beta (95% CI) = −0.22 (−0.34, −0.10), p = 3.90e-04) and Lachnospiraceae NK4A136 group (fixed-effect beta (95% CI) = −0.09 (−0.13, −0.05), p = 2.53e-06) were found to be the best predictors of anxiety and depressive symptoms, respectively, across our three cohorts and published literature taking into account demographic and lifestyle covariates, such as fibre intake. The association with anxiety was robust in accounting for heterogeneity between cohorts and supports previous observations of the potential prophylactic effect of Bifidobacterium against anxiety symptoms. Symptoms of anxiety and depression are associated with the gut microbiota. Five bacterial genera are associated with anxiety and depressive symptoms. Associations were stronger in two chronic pain cohorts than in controls. A meta-analysis found Bifidobacterium associated with lower anxiety symptoms. Our results agree with observations of probiotic supplementation reducing anxiety.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
16.6
作者：
Bosch, Jos A.;Nieuwdorp, Max;Zwinderman, Aeilko H.;Deschasaux, Melanie;Radjabzadeh, Djawad;Kraaij, Robert;Davids, Mark;de Rooij, Susanne R.;Lok, Anja
通讯作者：
Lok, Anja
影响因子：
7
作者：
Akin-Akinyosoye K;James RJE;McWilliams DF;Millar B;das Nair R;Ferguson E;Walsh DA
通讯作者：
Walsh DA
影响因子：
3.2
作者：
Chen JJ;Zheng P;Liu YY;Zhong XG;Wang HY;Guo YJ;Xie P
通讯作者：
Xie P
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer