The gut microbiota and depressive symptoms across ethnic groups.
The gut microbiota and depressive symptoms across ethnic groups.
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DOI：
10.1038/s41467-022-34504-1
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发表时间：
2022-12-06
影响因子：
16.6
通讯作者：
Lok, Anja
中科院分区：
文献类型：
--
作者：
Bosch, Jos A.;Nieuwdorp, Max;Zwinderman, Aeilko H.;Deschasaux, Melanie;Radjabzadeh, Djawad;Kraaij, Robert;Davids, Mark;de Rooij, Susanne R.;Lok, Anja
肠道微生物群被认为在抑郁症中发挥作用，这使其成为一个有吸引力的干预目标。微生物组和抑郁症状水平在不同种族之间差异很大。因此，任何针对微生物组的抑郁症干预都需要了解不同种族的微生物组与抑郁症的关联。通过分析HELIUS队列的数据，我们对生活在同一城市地区的6个种族（荷兰人、南亚苏里南人、非洲苏里南人、加纳人、土耳其人、摩洛哥人；N = 3211）的肠道微生物群及其与抑郁症状的关系进行了表征。肠道菌群的多样性，无论是体内的（α-多样性）还是个体之间的（β-多样性），在考虑人口统计学、行为和医学差异的情况下，都能预测抑郁症状的水平。这些联系在种族群体之间并无不同。此外，β多样性解释了29%-18%的抑郁症状的种族差异。与抑郁症状相关的细菌属属于多个科，主要包括Christensenellaceae， Lachnospiraceae和Ruminococcaceae。总之，研究结果表明，肠道微生物群与抑郁症状水平有关，而且这种联系在不同种族群体中普遍存在。此外，研究结果表明，肠道菌群的种族差异可能部分解释了抑郁症的相似差异。在这里，通过研究多种族横断面城市队列（N = 3211,6个种族），作者表明抑郁症状水平与肠道微生物群分类特征有关，但这些特征在不同种族之间基本不变。
The gut microbiome is thought to play a role in depressive disorders, which makes it an attractive target for interventions. Both the microbiome and depressive symptom levels vary substantially across ethnic groups. Thus, any intervention for depression targeting the microbiome requires understanding of microbiome-depression associations across ethnicities. Analysing data from the HELIUS cohort, we characterize the gut microbiota and its associations with depressive symptoms in 6 ethnic groups (Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish, Moroccan; N = 3211), living in the same urban area. Diversity of the gut microbiota, both within (α-diversity) and between individuals (β-diversity), predicts depressive symptom levels, taking into account demographic, behavioural, and medical differences. These associations do not differ between ethnic groups. Further, β-diversity explains 29%–18% of the ethnic differences in depressive symptoms. Bacterial genera associated with depressive symptoms belong to mulitple families, prominently including the families Christensenellaceae, Lachnospiraceae, and Ruminococcaceae. In summary, the results show that the gut microbiota are linked to depressive symptom levels and that this association generalizes across ethnic groups. Moreover, the results suggest that ethnic differences in the gut microbiota may partly explain parallel disparities in depression. Here, by studying a multi-ethnic cross-sectional urban cohort (N = 3211, 6 ethnic groups), the authors show that depressive symptom levels are related to the gut microbiota taxonomic characteristics but that these are largely invariant across ethnic groups.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
16.6
作者：
Duvallet C;Gibbons SM;Gurry T;Irizarry RA;Alm EJ
通讯作者：
Alm EJ
影响因子：
5.2
作者：
Castellanos, Nazareth;Diez, Gustavo G.;Larrosa, Mar
通讯作者：
Larrosa, Mar
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.