Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects.
Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects.
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DOI：
10.1167/iovs.64.7.30
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发表时间：
2023-06-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
Tissue stiffening and alterations in retinal blood flow have both been suggested as causative mechanisms of glaucomatous damage. We tested the hypothesis that retinal blood vessels also stiffen, using laser speckle flowgraphy (LSFG) to characterize vascular resistance. In the longitudinal Portland Progression Project, 231 eyes of 124 subjects received LSFG scans of the optic nerve head (ONH) and automated perimetry every 6 months for six visits. Eyes were classified as either “glaucoma suspect” or “glaucoma” eyes based on the presence of functional loss on the first visit. Vascular resistance was quantified using the mean values of several instrument-defined parameterizations of the pulsatile waveform measured by LSFG, either in major vessels within the ONH (serving the retina) or in capillaries within ONH tissue, and age-adjusted using a separate group of 127 healthy eyes of 63 individuals. Parameters were compared against the severity and rate of change of functional loss using mean deviation (MD) over the six visits, within the two groups. Among 118 “glaucoma suspect” eyes (average MD, −0.4 dB; rate, −0.45 dB/y), higher vascular resistance was related to faster functional loss, but not current severity of loss. Parameters measured in major vessels were stronger predictors of rate than parameters measured in tissue. Among 113 “glaucoma” eyes (average MD, −4.3 dB; rate, −0.53 dB/y), higher vascular resistance was related to more severe current loss but not rate of loss. Higher retinal vascular resistance and, by likely implication, stiffer retinal vessels were associated with more rapid functional loss in eyes without significant existing loss at baseline.
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DOI：
10.2147/opth.s22093
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
通讯作者：
Nakazawa T
影响因子：
3.5
作者：
Fazio, Massimo A.;Grytz, Rafael;Morris, Jeffrey S.;Bruno, Luigi;Gardiner, Stuart K.;Girkin, Christopher A.;Downs, J. Crawford
通讯作者：
Downs, J. Crawford
影响因子：
4.4
作者：
Gardiner SK;Mansberger SL;Demirel S
通讯作者：
Demirel S
影响因子：
--
作者：
ASMAN, P;HEIJL, A
通讯作者：
HEIJL, A
影响因子：
3
作者：
Matsumoto M;Suzuma K;Akiyama F;Yamada K;Harada S;Tsuiki E;Kitaoka T
通讯作者：
Kitaoka T