Retinal Microvascular Resistance Estimated from Waveform Analysis Is Significantly Higher With a Threshold Value in Central Retinal Vein Occlusion.
Retinal Microvascular Resistance Estimated from Waveform Analysis Is Significantly Higher With a Threshold Value in Central Retinal Vein Occlusion.
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DOI：
10.1167/tvst.9.11.4
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发表时间：
2020-12
影响因子：
3
通讯作者：
Kitaoka T
中科院分区：
文献类型：
--
作者：
Matsumoto M;Suzuma K;Akiyama F;Yamada K;Harada S;Tsuiki E;Kitaoka T
视网膜中央静脉阻塞（CRVO）的血流检测有助于了解CRVO的严重程度。实际血流量可以通过CRVO中视网膜静脉的电阻率来确定。我们以前评估平均模糊率（MBR），以反映总的视网膜血流速度在CRVO的情况下，使用激光散斑血流图（LSFG）。本研究使用LSFG的总毛细血管阻力（TCR）新指数评估CRVO病例的视网膜总血管阻力。我们测量了2009年至2016年期间访问长崎大学医院的68名CRVO患者和42名年龄匹配的无全身性疾病的对照组的TCR。我们比较了对照眼、CRVO对侧眼和CRVO受累眼的TCR。然后从受试者工作特征曲线获得CRVO阈值。CRVO受累眼的MBR（20.3 ± 8.2）显著低于对照眼（37.5 ± 8.4; P < 0.01）和CRVO对侧眼（36.4 ± 10.0; P < 0.01，Dunn检验）。CRVO受累眼的TCR（1.20 ± 0.55）显著高于对照眼（0.68 ± 0.2; P < 0.01）和CRVO对侧眼（0.81 ± 0.28; P < 0.01，Dunn检验）。CRVO存在的阈值为0.93，曲线下面积为0.84。通过测量除MBR之外的TCR，可以获得关于CRVO病理学的更详细的信息。治疗前后的数值比较可能有助于评价治疗效果。
Evaluation of blood flow is useful for understanding the severity of central retinal vein occlusion (CRVO). Actual blood flow may be determined by the resistivity of the retinal vein in CRVO. We have previously evaluated mean blur rate (MBR) to reflect total retinal blood flow velocity in CRVO cases using laser speckle flowgraphy (LSFG). This study evaluated retinal total vascular resistance in CRVO cases using the new index of total capillary resistance (TCR) from LSFG. We measured the TCR of 68 CRVO patients who visited Nagasaki University Hospital between 2009 and 2016 and 42 age-matched controls without systemic disease. We compared TCRs among control eyes, CRVO fellow eyes, and CRVO affected eyes. A CRVO threshold value was then obtained from the receiver operating characteristic curve. MBR was significantly lower for CRVO affected eyes (20.3 ± 8.2) than for control eyes (37.5 ± 8.4; P < 0.01) and CRVO fellow eyes (36.4 ± 10.0; P < 0.01, Dunn's test). TCR was significantly higher for CRVO affected eyes (1.20 ± 0.55) than for control eyes (0.68 ± 0.2; P < 0.01) and CRVO fellow eyes (0.81 ± 0.28; P < 0.01, Dunn's test). The threshold for the presence of CRVO was 0.93 and area under the curve was 0.84. By measuring TCR in addition to MBR, more detailed information regarding CRVO pathology can be obtained. Comparison of values before and after treatment may be useful for evaluating the effects of treatment.
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影响因子：
4.6
作者：
Mikoshiba Y;Iwase T;Ueno Y;Yamamoto K;Ra E;Terasaki H
通讯作者：
Terasaki H
DOI：
10.2147/opth.s22093
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
通讯作者：
Nakazawa T
DOI：
10.1097/iae.0000000000000586
发表时间：
2015-10
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Pinhas A;Dubow M;Shah N;Cheang E;Liu CL;Razeen M;Gan A;Weitz R;Sulai YN;Chui TY;Dubra A;Rosen RB
通讯作者：
Rosen RB
DOI：
10.1007/s00417-014-2927-5
发表时间：
2015-04-01
影响因子：
2.7
作者：
Hirooka, Kiriko;Saito, Wataru;Ishida, Susumu
通讯作者：
Ishida, Susumu
影响因子：
4.2
作者：
Ho, Jau-Der;Liou, Shiow-Wen;Lin, Herng-Ching
通讯作者：
Lin, Herng-Ching