Timing in cellular Ca2+ signaling.
Timing in cellular Ca2+ signaling.
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DOI:
10.1016/j.cub.2008.07.018
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发表时间:
2008-09-09
期刊:
影响因子:
9.2
通讯作者:
Marchant, Jonathan S.
中科院分区:
文献类型:
--
作者:
Boulware, Michael J.;Marchant, Jonathan S.
Calcium (Ca2+) signals are generated across a broad time range. Kinetic considerations impact how information is processed to encode and decode Ca2+ signals, the choreography of responses that ensure specific and efficient signaling and the overall temporal gearing such that ephemeral Ca2+ signals have lasting physiological value. The reciprocal importance of timing for Ca2+ signaling, and Ca2+ signaling for timing is exemplified by the altered kinetic profiles of Ca2+ signals in certain diseases and the likely role of basal Ca2+ fluctuations in the perception of time itself.
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