Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study.
Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study.
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DOI：
10.3390/nu13124466
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发表时间：
2021-12-14
期刊：
影响因子：
5.9
通讯作者：
Irie Y
中科院分区：
文献类型：
--
作者：
Kageyama S;Inoue R;Hosomi K;Park J;Yumioka H;Suka T;Kurohashi Y;Teramoto K;Syauki AY;Doi M;Sakaue H;Mizuguchi K;Kunisawa J;Irie Y
痉挛是严重运动和智力残疾（SMID）患者的常见并发症。本研究的目的是调查SMID患者的便秘症状和肠道微生物群的变化，这些变化与日本发酵食品麦芽米Amazake的摄入有关。10名患者食用测试食物6周，并调查他们的身体状况、饮食和药物状况以及便秘评估量表（CAS）。使用16 S rRNA序列方法进行了全面的粪便微生物组分析。结果表明，食用麦芽米Amazake后，CAS显著降低，乳酸杆菌显著增加，土氏志贺菌减少。为了研究麦芽米amazake消费的影响的差异，基于原始肠道微生物群的特征，患者根据干预前肠道微生物群的相似性进行分组;富含厚壁菌的组1（n = 5），富含放线菌的组2（n = 4）和富含变形菌的组3（n = 1）。第1组和第2组的CAS降低。双歧杆菌的相对丰度在总体和第1组中均显示出增加的趋势，但在第2组中最初较高。我们的研究结果表明，麦芽米Amazake消费减少便秘症状，同时改变肠道微生物群，但变化可能取决于肠道微生物群的原始组成。
Constipation is a frequent complication in patients with severe motor and intellectual disabilities (SMID). The aim of this study was to investigate changes in constipation symptoms and gut microbiota associated with the intake of malted rice amazake, a fermented food in Japan, in patients with SMID. Ten patients consumed the test food for six weeks, and their physical condition, dietary and medication status, and constipation assessment scale (CAS) were investigated. Comprehensive fecal microbiome analysis using the 16S rRNA sequence method was performed. The results showed a significant decrease in CAS, and a significant increase in Lactobacillales and decrease in Escherichia-Shigella after consuming malted rice amazake. To investigate the difference in the effects of malted rice amazake consumption, based on the characteristics of the original gut microbiota, the patients were grouped according to the similarity of their gut microbiota before the intervention; Firmicutes-rich Group 1 (n = 5), Actinobacteria-rich Group 2 (n = 4), and Proteobacteria-rich Group 3 (n = 1). The CAS decreased in Groups 1 and 2. The relative abundance of Bifidobacterium showed an increasing tendency both overall and in Group 1, but it was originally higher in Group 2. Our results suggest that malted rice amazake consumption reduces constipation symptoms and simultaneously changes the gut microbiota, but the changes may vary depending on the original composition of the gut microbiota.
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影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
3.9
作者：
Furuta A;Suzuki Y;Takahashi R;Jakobsen BP;Kimura T;Egawa S;Yoshimura N
通讯作者：
Yoshimura N
影响因子：
4.6
作者：
Hosomi K;Ohno H;Murakami H;Natsume-Kitatani Y;Tanisawa K;Hirata S;Suzuki H;Nagatake T;Nishino T;Mizuguchi K;Miyachi M;Kunisawa J
通讯作者：
Kunisawa J
DOI：
10.1152/ajpregu.00442.2002
发表时间：
2003-05-01
影响因子：
2.8
作者：
Fukumoto, S;Tatewaki, M;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
29.4
作者：
KAMATH, PS;PHILLIPS, SF;ZINSMEISTER, AR
通讯作者：
ZINSMEISTER, AR