Serum fatty acids profile and association with early-onset coronary artery disease.
Serum fatty acids profile and association with early-onset coronary artery disease.
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血清脂肪酸谱及其与早发性冠状动脉疾病的关联
DOI：
10.1177/20406223211033102
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发表时间：
2021
影响因子：
3.5
通讯作者：
Lun LM
中科院分区：
文献类型：
--
作者：
Xuan C;Tian QW;Li H;Guo JJ;He GW;Lun LM
背景：脂肪酸在调节和预防人类疾病方面发挥着重要作用，包括早发性冠状动脉疾病(EOCAD)。在这项研究中，我们的目的是提供EOCAD患者血清中FA的概况，并确定潜在的EOCAD相关FA。方法：在第一阶段，我们用气相色谱-质谱法分析了EOCAD患者混合样品中的FAs谱。在第二阶段，对EOCAD患者的候选FAs水平进行了验证。结果：共纳入128例EOCAD患者和对照组。在混合样本中对49个血清FA进行了定量；3个ω-3 FA被鉴定为与EOCAD相关。此外，验证阶段的结果显示，EOCAD患者(55.43 ± 33.86 /ml)和心肌梗死(MI)患者(47.49 ± 28.44 μ/ml)的血清二十二碳六烯酸(DHA)水平显著低于对照组(70.65 ± 43.56 /ml)。多因素回归分析显示，血清DHA水平升高是EOCAD[优势比(OR) = 0.8917，95%可信区间(CI)：0.879~0.957]和MI(OR = 0.835，95%CI：0.799~0.862)的独立保护因素。观察到早发性心肌梗塞患者血清二十二碳五烯酸(DPA)和二十碳五烯酸(EPA)水平降低。结论：本研究提供了EOCAD患者的血清FAs谱，并证实血清DHA、DPA和EPA水平的降低与EOCAD有关。这些发现可能有助于理解FAs的心血管效应，特别是ω-3多不饱和FAs的保护作用。
Background: Fatty acids (FAs) play crucial roles in modulating and preventing diseases in humans, including early-onset coronary artery disease (EOCAD). In this study, we aimed to provide a profile of FAs in the serum of EOCAD patients and identify potential EOCAD-associated FAs. Methods: In the first stage, we analyzed the FAs profiles in pooled samples of patients with EOCAD using gas chromatography-mass spectrometry. In the second stage, the serum levels of the candidate FAs were validated in EOCAD patients. Results: A total of 128 EOCAD patients and 64 controls were included in the study. Forty-nine serum FAs were quantified in pooled samples; three ω-3 FAs were identified to be associated with EOCAD. Moreover, results from the validation stage indicated that serum levels of docosahexaenoic acid (DHA) were significantly lower in EOCAD patients (55.43 ± 33.86 µg/ml) and myocardial infarction (MI) patients (47.49 ± 28.44 μg/ml) than those in the controls (70.65 ± 43.56 µg/ml). Multivariate regression analysis revealed that elevated serum DHA level was an independent protective factor for EOCAD [odds ratio (OR) = 0.8917, 95% confidence interval (CI): 0.879–0.957] and MI (OR = 0.835, 95% CI: 0.799–0.862). Decreased serum levels of docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA) were observed in the early-onset MI group. Conclusion: The study provided the serum FAs profile of EOCAD and confirmed that the decrease in serum levels of DHA, DPA, and EPA was associated with EOCAD. These findings might contribute to understanding the cardiovascular effects of FAs, particularly the protective effects of ω-3 polyunsaturated FAs.
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影响因子：
5.9
作者：
Schwingshackl L;Hoffmann G
通讯作者：
Hoffmann G
影响因子：
4.4
作者：
Pang, Jing;Poulter, Elissa B.;Watts, Gerald F.
通讯作者：
Watts, Gerald F.
影响因子：
11
作者：
Ghosh A;Gao L;Thakur A;Siu PM;Lai CWK
通讯作者：
Lai CWK
影响因子：
24
作者：
Aung T;Halsey J;Kromhout D;Gerstein HC;Marchioli R;Tavazzi L;Geleijnse JM;Rauch B;Ness A;Galan P;Chew EY;Bosch J;Collins R;Lewington S;Armitage J;Clarke R;Omega-3 Treatment Trialists’ Collaboration
通讯作者：
Omega-3 Treatment Trialists’ Collaboration
影响因子：
4.2
作者：
Dietschy, JM
通讯作者：
Dietschy, JM