The effect of injury timing on white matter changes in the corpus callosum following unilateral brain injury.
The effect of injury timing on white matter changes in the corpus callosum following unilateral brain injury.
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DOI：
10.1016/j.nicl.2013.08.002
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Dewald JP
中科院分区：
文献类型：
--
作者：
Hawe RL;Sukal-Moulton T;Dewald JP
单侧脑损伤后的运动障碍可能与胼胝体的变化有关。本研究的目的是确定胼胝体在儿童和成人偏瘫中是否受到不同的影响。对41名参与者（11名儿童偏瘫，10名成人偏瘫，10名儿童对照和10名成人对照）完成了弥散张量成像。各组间比较胼胝体五个区域的各向异性分数值和横截面积。此外，在非麻痹性肘关节屈曲任务中，对一部分儿童偏瘫参与者的麻痹性肘关节不自主活动量进行量化。与儿童对照组相比，儿童偏瘫患者的胼胝体区（对应于运动前区和辅助运动区、初级感觉皮质、顶叶、颞叶和枕叶皮质）的各向异性分数值降低。成人中风和成人对照组之间的分数各向异性的差异仅在对应于顶叶、颞叶和枕叶皮质的区域发现。横截面积的影响，在所有地区的胼胝体在小儿偏瘫，但只有在初级感觉区在成人偏瘫。此外，在儿童偏瘫组中，横截面积的变化与不自主镜像运动相关。总之，与成人偏瘫相比，儿童胼胝体受影响的程度更大，这可能解释了为什么未抑制的镜像运动和双手协调困难在这一人群中是更大的问题。应用DTI技术对小儿和成人偏瘫患者胼胝体进行对比研究。小儿偏瘫患者的各向异性分数降低。儿童偏瘫患者胼胝体横截面积减少。与小儿偏瘫相比，成人偏瘫对胼胝体的影响较小。胼胝体的变化与双手协调缺陷相关。
Motor impairments following unilateral brain injuries may be related to changes in the corpus callosum. The purpose of this study was to determine if the corpus callosum is impacted differently in pediatric versus adult hemiplegia. Diffusion tensor imaging was completed on 41 participants (11 pediatric hemiplegia, 10 adult hemiplegia, 10 pediatric control and 10 adult control). Fractional anisotropy values and cross-sectional areas for five regions of the corpus callosum were compared between subject groups. Additionally, the amount of involuntary activity in the paretic elbow was quantified during non-paretic elbow flexion tasks for a subset of pediatric hemiplegia participants. Fractional anisotropy values were reduced in pediatric hemiplegia compared to pediatric control subjects in callosal regions corresponding to premotor and supplementary motor areas, primary sensory cortex, and parietal, temporal, and occipital cortices. Differences in fractional anisotropy between adult stroke and adult controls were only found in the region corresponding to parietal, temporal, and occipital cortices. Cross-sectional area was affected in all regions of the corpus callosum in pediatric hemiplegia, but only in the primary sensory region in adult hemiplegia. Additionally, changes in the cross-sectional areas were correlated with involuntary mirror movements in the pediatric hemiplegia group. In conclusion, the corpus callosum is affected to a greater extent in pediatric compared to adult hemiplegia, which may explain why unsuppressed mirror movements and difficulty with bimanual coordination are greater problems in this population. DTI was used to compare the corpus callosum between pediatric and adult hemiplegia. Pediatric hemiplegia subjects had decreased fractional anisotropy. Cross-sectional area of the corpus callosum was reduced in pediatric hemiplegia. Corpus callosum was less affected in adult hemiplegia versus pediatric hemiplegia. Corpus callosum changes were correlated with bimanual coordination deficits.
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影响因子：
2.7
作者：
Kulak, W.;Sobaniec, W.;Okurowska-Zawada, B.
通讯作者：
Okurowska-Zawada, B.
影响因子：
6.7
作者：
Koerte, Inga;Heinen, Florian;Ertl-Wagner, Birgit
通讯作者：
Ertl-Wagner, Birgit
影响因子：
3.7
作者：
Moses, P;Courchesne, E;Edwards, E
通讯作者：
Edwards, E
影响因子：
3.7
作者：
Fling, B. W.;Seidler, R. D.
通讯作者：
Seidler, R. D.
影响因子：
3.8
作者：
Carr, LJ
通讯作者：
Carr, LJ