Structural and functional brain changes in perimenopausal women who are susceptible to migraine: a study protocol of multi-modal MRI trial.
Structural and functional brain changes in perimenopausal women who are susceptible to migraine: a study protocol of multi-modal MRI trial.
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易患偏头痛的围绝经期女性的大脑结构和功能变化：多模态 MRI 试验的研究方案
DOI：
10.1186/s12880-018-0272-6
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发表时间：
2018-09-06
影响因子：
2.7
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Hu B;Wang X;He JB;Dai YJ;Zhang J;Yu Y;Sun Q;Lin-FengYan;Hu YC;Nan HY;Yang Y;Kaye AD;Cui GB;Wang W
偏头痛是困扰中年女性的常见临床症状，与围绝经期密切相关。以往的研究表明，最突出的诱因之一是围绝经期雌激素的突然下降。激素替代疗法（HRT）被广泛用于预防围绝经期妇女的这种痛苦，但缺乏有效的诊断系统来量化疾病的严重程度。为了避免HRT的滥用和过度使用，我们建议使用多模式MRI技术进行诊断试验，以量化这些易受雌激素下降影响的围月经期偏头痛患者的严重程度。患有偏头痛的围绝经期妇女将从我们医院的疼痛诊所招募。将从当地社区招募没有任何头痛的围绝经期妇女。将进行临床评估和多模态MR成像检查。3年内每半年进行一次随访。疼痛行为、神经心理学评分、功能磁共振成像分析结合适当的统计软件将被用来揭示这些特征与偏头痛易感性之间的潜在联系。将获得健康对照组和易受雌激素下降影响的围绝经期妇女的多模态成像特征。成像特征将包括体积特征、白色物质完整性、功能特征、拓扑特性和灌注特性。临床信息，如基本信息、血雌激素水平、偏头痛信息和一系列神经系统量表也将用于统计评估。本临床试验将有助于建立一个有效的筛查系统，以量化这些易感妇女在围绝经期的疾病严重程度。该研究已在临床试验中注册。gov（ID：NCT02820974）.注册日期：2014年9月28日。
As a common clinical symptom that often bothers midlife females, migraine is closely associated with perimenopause. Previous studies suggest that one of the most prominent triggers is the sudden decline of estrogen during perimenopausal period. Hormone replacement therapy (HRT) is widely used to prevent this suffering in perimenopausal women, but effective diagnostic system is lacked for quantifying the severity of the diseaase. To avoid the abuse and overuse of HRT, we propose to conduct a diagnostic trial using multimodal MRI techniques to quantify the severity of these perimenopausal migraineurs who are susceptible to the decline of estrogen. Perimenopausal women suffering from migraine will be recruited from the pain clinic of our hospital. Perimenopausal women not suffering from any kind of headache will be recruited from the local community. Clinical assessment and multi-modal MR imaging examination will be conducted. A follow up will be conducted once half year within 3 years. Pain behavior, neuropsychology scores, fMRI analysis combined with suitable statistical software will be used to reveal the potential association between these above traits and the susceptibility of migraine. Multi-modal imaging features of both healthy controls and perimenopausal women who are susceptible to estrogen decline will be acquired. Imaging features will include volumetric characteristics, white matter integrity, functional characteristics, topological properties, and perfusion properties. Clinical information, such as basic information, blood estrogen level, information of migraine, and a bunch of neurological scale will also be used for statistic assessment. This clinical trial would help to build an effective screen system for quantifying the severity of illness of those susceptible women during the perimenopausal period. This study has already been registered at Clinical Trials. gov (ID: NCT02820974). Registration date: September 28th, 2014.
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DOI：
10.1016/j.mrfmmm.2005.06.013
发表时间：
2005-12-30
影响因子：
2.3
作者：
Hayes, RB;Sigurdson, A;Berg, CD
通讯作者：
Berg, CD
影响因子：
4.9
作者：
Cadiot, Domitille;Longuet, Romain;Proisy, Maia
通讯作者：
Proisy, Maia
影响因子：
5
作者：
Burch, Rebecca C.;Loder, Stephen;Smitherman, Todd A.
通讯作者：
Smitherman, Todd A.
影响因子：
3.4
作者：
Gil-Gouveia R;Pinto J;Figueiredo P;Vilela PF;Martins IP
通讯作者：
Martins IP
影响因子：
5
作者：
Buse, Dawn C.;Loder, Elizabeth W.;Lipton, Richard B.
通讯作者：
Lipton, Richard B.