Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history.
Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history.
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DOI：
10.1038/s42003-023-05388-8
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发表时间：
2023-10-13
影响因子：
5.9
通讯作者：
Dunstan, Sarah J.
中科院分区：
文献类型：
--
作者：
Silcocks, Matthew;Dunstan, Sarah J.
两层假说正迅速成为描述东亚人口历史的热门叙事。在这种模式下，最初通过喜马拉雅山脉以南的路线居住在东亚的狩猎采集群体，被通过穿越欧亚大陆的北部路线抵达的农业移民同化。由于缺乏来自热带东亚的古代样本，限制了这一模型的分辨率。我们通过分析结核分枝杆菌(Mtb)与人类Y染色体的系统地理特征，认为人类病原体结核分枝杆菌(Mtb)内的变异模式提供了洞察力。我们展示了与东亚第一层人口相关的传统狩猎-采集群体中丰富的Y染色体谱系，表现出根深蒂固、低长期有效种群规模以及与南方进入路线一致的多样性格局。这些特征反映了进化上古老的Mtb血统1的特征。剩余的东亚Y染色体血统几乎完全不存在于传统的狩猎-采集群体中，并表现出与南方进入路线不相容的时空特征，并将其与现代中国的农业发展联系起来。这些特征反映了进化上现代的结核分枝杆菌谱系2的特征。这一模式为东亚新的宿主-病原体共同进化研究假说铺平了道路。东亚结核分枝杆菌谱系的系统地理模式反映了人类Y染色体单倍群的模式，支持两层假说，并支持旧石器时代结核分枝杆菌复合体的出现情景。
The Two Layer hypothesis is fast becoming the favoured narrative describing East Asian population history. Under this model, hunter-gatherer groups who initially peopled East Asia via a route south of the Himalayas were assimilated by agriculturalist migrants who arrived via a northern route across Eurasia. A lack of ancient samples from tropical East Asia limits the resolution of this model. We consider insight afforded by patterns of variation within the human pathogen Mycobacterium tuberculosis (Mtb) by analysing its phylogeographic signatures jointly with the human Y-chromosome. We demonstrate the Y-chromosome lineages enriched in the traditionally hunter-gatherer groups associated with East Asia’s first layer of peopling to display deep roots, low long-term effective population size, and diversity patterns consistent with a southern entry route. These characteristics mirror those of the evolutionarily ancient Mtb lineage 1. The remaining East Asian Y-chromosome lineage is almost entirely absent from traditionally hunter-gatherer groups and displays spatial and temporal characteristics which are incompatible with a southern entry route, and which link it to the development of agriculture in modern-day China. These characteristics mirror those of the evolutionarily modern Mtb lineage 2. This model paves the way for novel host-pathogen coevolutionary research hypotheses in East Asia. The phylogeographic patterns of Mycobacterium tuberculosis lineages in East Asia mirror those of human Y-chromosome haplogroups, supporting the Two Layer hypothesis, and a Paleolithic emergence scenario for the Mycobacterium tuberculosis complex.
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影响因子：
3.7
作者：
He JD;Peng MS;Quang HH;Dang KP;Trieu AV;Wu SF;Jin JQ;Murphy RW;Yao YG;Zhang YP
通讯作者：
Zhang YP
影响因子：
64.8
作者：
Bos KI;Harkins KM;Herbig A;Coscolla M;Weber N;Comas I;Forrest SA;Bryant JM;Harris SR;Schuenemann VJ;Campbell TJ;Majander K;Wilbur AK;Guichon RA;Wolfe Steadman DL;Cook DC;Niemann S;Behr MA;Zumarraga M;Bastida R;Huson D;Nieselt K;Young D;Parkhill J;Buikstra JE;Gagneux S;Stone AC;Krause J
通讯作者：
Krause J
影响因子：
9.2
作者：
Cordaux, R;Aunger, R;Stoneking, M
通讯作者：
Stoneking, M
影响因子：
3.7
作者：
Colangeli R;Arcus VL;Cursons RT;Ruthe A;Karalus N;Coley K;Manning SD;Kim S;Marchiano E;Alland D
通讯作者：
Alland D
影响因子：
16.8
作者：
Biek R;Pybus OG;Lloyd-Smith JO;Didelot X
通讯作者：
Didelot X