Enhanced size-dependent trapping of particles using microvortices.
Enhanced size-dependent trapping of particles using microvortices.
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DOI：
10.1007/s10404-013-1176-y
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发表时间：
2013-11-01
影响因子：
2.8
通讯作者：
Papautsky, Ian
中科院分区：
文献类型：
--
作者：
Zhou, Jian;Kasper, Susan;Papautsky, Ian
惯性微流体技术在基于尺寸的颗粒和细胞分离方面引起了人们极大的兴趣。惯性力可以通过扩展微通道几何形状来操纵，导致形成微涡旋，其选择性地从混合物中分离和捕获颗粒或细胞。在这项工作中，我们的目标是提高我们的理解，在这样的微涡颗粒捕获通过开发一个模型的选择性颗粒捕获。设计和操作参数，包括流动条件，捕获区域的大小，和目标颗粒浓度进行了探讨，以阐明其对捕获行为的影响。我们的研究结果表明，捕获的尺寸依赖性的特征在于由一个阈值雷诺数，这决定了选择性进入的颗粒从主流的微涡。我们表明，在100，000 ×的数量级上的浓度增强和在1/mL的浓度下的靶的分离是可能的。最终，从我们的系统研究中获得的见解建议优化解决方案，提高器件性能（效率，尺寸选择性和产量），并适用于选择性分离和捕获大型稀有细胞以及其他应用。
Inertial microfluidics has been attracting considerable interest for size-based separation of particles and cells. The inertial forces can be manipulated by expanding the microchannel geometry, leading to formation of microvortices which selectively isolate and trap particles or cells from a mixture. In this work, we aim to enhance our understanding of particle trapping in such microvortices by developing a model of selective particle trapping. Design and operational parameters including flow conditions, size of the trapping region, and target particle concentration are explored to elucidate their influence on trapping behavior. Our results show that the size dependence of trapping is characterized by a threshold Reynolds number, which governs the selective entry of particles into microvortices from the main flow. We show that concentration enhancement on the order of 100,000× and isolation of targets at concentrations in the 1/mL is possible. Ultimately, the insights gained from our systematic investigation suggest optimization solutions that enhance device performance (efficiency, size selectivity, and yield) and are applicable to selective isolation and trapping of large rare cells as well as other applications.
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影响因子：
6.1
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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