Nanoparticle location and material dependent dose enhancement in X-ray radiation therapy.
Nanoparticle location and material dependent dose enhancement in X-ray radiation therapy.
复制标题
DOI：
10.1021/jp306543q
复制
发表时间：
2012-11-01
影响因子：
3.7
通讯作者：
Su, Ming
中科院分区：
文献类型：
--
作者：
Hossain, Mainul;Su, Ming
高原子序数（Z）材料的纳米颗粒可以充当放射增敏剂，以增强递送至肿瘤的辐射剂量。通过考虑光电子和俄歇电子的贡献，采用分析方法来计算相对于细胞核位于不同位置的一系列纳米颗粒（铋、金和铂）对肿瘤内皮细胞及其细胞核的剂量增强。使用和不使用纳米粒子递送至细胞的剂量之比称为剂量增强因子（DEF）。 DEF 取决于纳米颗粒的材料成分、尺寸以及相对于细胞和细胞核的位置。照射X射线束的能量影响纳米粒子对X射线的吸收，在剂量增强中发挥重要作用。对于诊断 X 射线源，对于给定的纳米颗粒尺寸、浓度和位置，铋纳米颗粒比金和铂纳米颗粒提供更高的剂量增强。位于最接近原子核的纳米粒子获得了最高的 DEF，其中短程俄歇电子的能量沉积最大。对于直径范围在 2-400 nm 之间的纳米颗粒，剂量增强随着颗粒尺寸的减小而增加。这些结果有助于寻找纳米颗粒增强癌症 X 射线放射治疗的优化条件。
Nanoparticles of high atomic number (Z) materials can act as radiosensitizers to enhance radiation dose delivered to tumors. An analytical approach is used to calculate dose enhancements to tumor endothelial cells and their nuclei for a series of nanoparticles (bismuth, gold and platinum) located at different locations relative to nuclei by considering contributions from both photoelectrons and Auger electrons. The ratio of the dose delivered to cells with and without the nanoparticles is known as the dose enhancement factor (DEF). DEFs depend on material composition, size and location of nanoparticles with respect to the cell and the nucleus. Energy of irradiating X-ray beam affects X-ray absorption by nanoparticles and plays an important role in dose enhancements. For diagnostic X-ray sources, bismuth nanoparticles provide higher dose enhancements than gold and platinum nanoparticles for a given nanoparticle size, concentration and location. The highest DEFs are achieved for nanoparticles located closest to the nucleus where energy depositions from short range Auger electrons are maximum. With nanoparticles ranging in diameter between 2-400 nm, the dose enhancement increases with decrease in particle size. The results are useful in finding optimized conditions for nanoparticle enhanced X-ray radiation therapy of cancer.
登录
查看更多内容
影响因子：
3.5
作者：
Cho, SH
通讯作者：
Cho, SH
影响因子：
--
作者：
Praetorius, Natalie P;Mandal, Tarun K
通讯作者：
Mandal, Tarun K
影响因子：
3.4
作者：
MUNRO, TR
通讯作者：
MUNRO, TR
影响因子：
15
作者：
Kang, Bin;Mackey, Megan A.;El-Sayed, Mostafa A.
通讯作者：
El-Sayed, Mostafa A.
影响因子：
0.6
作者：
Cho, Sungkoo;Jeong, Jong Hwi;Yoon, Myonggeun
通讯作者：
Yoon, Myonggeun