Use of the "Exposome" in the Practice of Epidemiology: A Primer on -Omic Technologies.
Use of the "Exposome" in the Practice of Epidemiology: A Primer on -Omic Technologies.
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DOI：
10.1093/aje/kwv325
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发表时间：
2016-08-15
影响因子：
5
通讯作者：
Schulte PA
中科院分区：
文献类型：
--
作者：
DeBord DG;Carreón T;Lentz TJ;Middendorf PJ;Hoover MD;Schulte PA
麻烦组被定义为个人一生中经历的暴露的总和以及这些暴露如何影响健康。已经确定了三个领域的麻烦：内部，具体的外部和一般的外部。内部因素是指个人独有的因素;具体的外部因素包括职业暴露和生活方式因素。一般外部域包括教育水平和财务状况等因素。引出麻烦是令人生畏的，目前不可行，可能永远不会完全实现。已经确定了各种工具来衡量麻烦。生物标志物测量将是生物组学研究的主要工具之一。然而，也可以从其他来源获得暴露数据，例如传感器、地理信息系统和常规工具，例如测量仪器。目前正在进行概念验证研究，这些研究显示出经济学调查和不同类型数据整合的前景。化学组学数据在流行病学研究中的固有价值在于，它们可以使人们更好地了解各种化学和其他风险因素与疾病之间的关系，并最终导致更有效和更高效的预防和控制。
The exposome has been defined as the totality of exposure individuals experience over their lives and how those exposures affect health. Three domains of the exposome have been identified: internal, specific external and general external. Internal factors are those that are unique to the individual; and specific external factors include occupational exposures and lifestyle factors. The general external domain includes factors such as education level and financial status. Eliciting the exposome is daunting and at present not feasible and may never be fully realized. A variety of tools has been identified to measure the exposome. Biomarker measurements will be one of the major tools in exposomic studies. However, exposure data can also be obtained from other sources such as sensors, geographic information systems and conventional tools such as survey instruments. Proof of concept studies are being conducted that show the promise of the exposomic investigation and the integration of different kinds of data. The inherent value of exposomic data in epidemiologic studies is that they can provide greater understanding of the relationships among a broad range of chemical and other risk factors and diseases and ultimately lead to more effective and efficient prevention and control.
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影响因子：
2
作者：
DeBord DG;Burgoon L;Edwards SW;Haber LT;Kanitz MH;Kuempel E;Thomas RS;Yucesoy B
通讯作者：
Yucesoy B
影响因子：
--
作者：
Eagle, Nathan;Pentland, Alex (Sandy)
通讯作者：
Pentland, Alex (Sandy)
影响因子：
15.8
作者：
Ioannidis, JPA
通讯作者：
Ioannidis, JPA
影响因子：
--
作者：
Li-Pook-Than J;Snyder M
通讯作者：
Snyder M
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y