Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study.
Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study.
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DOI：
10.1136/bmjopen-2021-054160
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发表时间：
2021-11-25
期刊：
影响因子：
2.9
通讯作者：
MacCabe J
中科院分区：
文献类型：
--
作者：
Millgate E;Kravariti E;Egerton A;Howes OD;Murray RM;Kassoumeri L;Donocik J;Lewis S;Drake R;Lawrie S;Murphy A;Collier T;Lees J;Stockton-Powdrell C;Walters J;Deakin B;MacCabe J
70%-84%抗精神病药物治疗耐药的个体自首次发作起无反应。新出现的横截面证据比较了治疗抵抗性精神分裂症和治疗反应性精神分裂症的认知特征，表明言语记忆和语言功能可能在治疗抵抗中受损更严重。我们试图通过比较抗精神病无反应者（NR）和反应者(R)的认知表现来证实这一发现，使用简短的精神分裂症认知电池，主要关注口头任务与其他认知测量相比较。横截面。这项横断面研究在英国四个地点招募了抗精神病药物R和抗精神病药物NR。使用精神分裂症患者认知能力简要评估（BACS）评估认知表现。106名年龄在18-65岁之间，诊断为精神分裂症或精神分裂样障碍的参与者根据他们的治疗反应被招募，其中52例为NR， 54例为R。BACS认知表现的综合和亚量表得分。采用单变量和多变量线性回归（经年龄、性别和病程调整）研究各组（R vs NR）认知评分的差异。单变量回归模型观察到，R组和NR组在BACS的任何测量上均无显著差异，包括言语记忆（ß= - 1.99, 95% CI - 6.63至2.66,p=0.398）和言语流畅性（ß=1.23, 95% CI - 2.46至4.91,p=0.510）。这种发现模式在多变量模型中是一致的。在我们的样本中缺乏认知的组差异可能是由于我们组之间缺乏临床区分。未来的研究应旨在使用纵向首发样本的机器学习方法来识别精神分裂症中的应答者亚型，以及认知因素如何在其中相互作用。娱乐:15 / LO / 0038。
70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophrenia has indicated that verbal memory and language functions may be more impaired in treatment resistance. We sought to confirm this finding by comparing cognitive performance between antipsychotic non-responders (NR) and responders (R) using a brief cognitive battery for schizophrenia, with a primary focus on verbal tasks compared against other measures of cognition. Cross-sectional. This cross-sectional study recruited antipsychotic treatment R and antipsychotic NR across four UK sites. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). One hundred and six participants aged 18–65 years with a diagnosis of schizophrenia or schizophreniform disorder were recruited according to their treatment response, with 52 NR and 54 R cases. Composite and subscale scores of cognitive performance on the BACS. Group (R vs NR) differences in cognitive scores were investigated using univariable and multivariable linear regressions adjusted for age, gender and illness duration. Univariable regression models observed no significant differences between R and NR groups on any measure of the BACS, including verbal memory (ß=−1.99, 95% CI −6.63 to 2.66, p=0.398) and verbal fluency (ß=1.23, 95% CI −2.46 to 4.91, p=0.510). This pattern of findings was consistent in multivariable models. The lack of group difference in cognition in our sample is likely due to a lack of clinical distinction between our groups. Future investigations should aim to use machine learning methods using longitudinal first episode samples to identify responder subtypes within schizophrenia, and how cognitive factors may interact within this. REC: 15/LO/0038.
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影响因子：
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作者：
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