The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study
The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study
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镍冶炼工人Nkx2.1与DNA氧化损伤修复的关系：金昌队列研究
DOI：
10.3390/ijerph16010120
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发表时间：
2019-01
影响因子：
--
通讯作者：
Yang Kehu
中科院分区：
文献类型：
--
作者：
Cheng Zhiyuan;Cheng Ning;Shi Dian;Ren Xiaoyu;Gan Ting;Bai Yana;Yang Kehu
背景：职业性镍暴露可引起DNA氧化损伤，影响DNA修复。然而，镍诱导肺癌高风险的潜在机制尚未完全了解。我们的研究旨在评估镍诱导的氧化损伤和DNA修复是否与Smad 2磷酸化状态和Nkx2.1表达水平的改变相关，Nkx2.1被认为是肺癌的起始基因。方法：从金昌市队列中随机抽取140名镍冶炼厂职工和140名年龄匹配的行政管理人员，按工龄分层。采用典型回归、χ2检验、斯皮尔曼相关等方法分析工龄与MDA、8-OHdG、hOGG 1、PARP、pSmad 2、Nkx 2. 1之间的关系。结果：MDA、PARP、pSmad 2和Nkx2.1浓度均显著升高。Nkx2.1（rs = 0.312，p < 0.001）和Smad 2磷酸化水平（rs = 0.232，p = 0.006）与镍冶炼厂的工作年限呈正相关，而在行政官员组中未观察到这一点。此外，镍冶炼厂Nkx2.1表达的升高与工龄、8-OHdG、PARP、hOGG 1和pSmad 2水平呈正相关。结论：职业性镍暴露可增加Nkx2.1和pSmad 2的表达，这与镍引起的氧化损伤和DNA修复改变有关。
Background: Occupational nickel exposure can cause DNA oxidative damage and influence DNA repair. However, the underlying mechanism of nickel-induced high-risk of lung cancer has not been fully understood. Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Methods: 140 nickel smelters and 140 age-matched administrative officers were randomly stratified by service length from Jinchang Cohort. Canonical regression, χ2 test, Spearman correlation etc. were used to evaluate the association among service length, MDA, 8-OHdG, hOGG1, PARP, pSmad2, and Nkx2.1. Results: The concentrations of MDA, PARP, pSmad2, and Nkx2.1 significantly increased. Nkx2.1 (rs = 0.312, p < 0.001) and Smad2 phosphorylation levels (rs = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters. Conclusions: Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change.
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影响因子：
6.2
作者：
Gadgeel, Shirish M.;Ali, Shadan;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.
DOI：
--
发表时间：
2001-07
期刊：
Research communications in molecular pathology and pharmacology
影响因子：
--
作者：
T. Stedeford;F. Cardozo‐Pelaez;C. Hover;R. Harbison;J. Sanchez-Ramos
通讯作者：
T. Stedeford;F. Cardozo‐Pelaez;C. Hover;R. Harbison;J. Sanchez-Ramos
DOI：
10.1016/j.mrgentox.2013.04.011
发表时间：
2013-08
期刊：
Mutation research
影响因子：
--
作者：
Minli Wang;Janapriya Saha;F. Cucinotta
通讯作者：
Minli Wang;Janapriya Saha;F. Cucinotta
影响因子：
5.6
作者：
Yatabe, Y;Mitsudomi, T;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
5.1
作者：
Lightfoot, N.;Berriault, C.;Semenciw, R.
通讯作者：
Semenciw, R.