Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension.
Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension.
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局部辅酶Q10在高眼压啮齿动物模型中显示了视网膜介导的神经保护作用。
DOI：
10.1016/j.mito.2017.05.010
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发表时间：
2017-09
期刊：
影响因子：
4.4
通讯作者：
Cordeiro MF
中科院分区：
文献类型：
--
作者：
Davis BM;Tian K;Pahlitzsch M;Brenton J;Ravindran N;Butt G;Malaguarnera G;Normando EM;Guo L;Cordeiro MF
Coenzyme Q10 (CoQ10) is a mitochondrial-targeted antioxidant with known neuroprotective activity. Its ocular effects when co-solubilised with α–tocopherol polyethylene glycol succinate (TPGS) were evaluated. In vitro studies confirmed that CoQ10 was significantly protective in different retinal ganglion cell (RGC) models. In vivo studies in Adult Dark Agouti (DA) rats with unilateral surgically-induced ocular hypertension (OHT) treated with either CoQ10/TPGS micelles or TPGS vehicle twice daily for three weeks were performed, following which retinal cell health was assessed in vivo using DARC (Detection of Apoptotic Retinal Cells) and post-mortem with Brn3a histological assessment on whole retinal mounts. CoQ10/TPGS showed a significant neuroprotective effect compared to control with DARC (p < 0.05) and Brn3 (p < 0.01). Topical CoQ10 appears an effective therapy preventing RGC apoptosis and loss in glaucoma-related models.
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影响因子：
9
作者：
通讯作者：
--
影响因子：
3
作者：
Fujimaki, Hisako;Inoue, Gen;Takaso, Masashi
通讯作者：
Takaso, Masashi
DOI：
10.1136/bjo.2008.144006
发表时间：
2009-08
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Duncan KG;Hosseini K;Bailey KR;Yang H;Lowe RJ;Matthes MT;Kane JP;LaVail MM;Schwartz DM;Duncan JL
通讯作者：
Duncan JL
影响因子：
9
作者：
通讯作者：
--
影响因子：
4.8
作者：
Galvao, Joana;Davis, Benjamin;Cordeiro, M. Francesca
通讯作者：
Cordeiro, M. Francesca