On the nature of peptides involved in T cell alloreactivity.
On the nature of peptides involved in T cell alloreactivity.
复制标题
关于参与T细胞的肽的性质。
DOI：
10.1084/jem.174.5.1059
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发表时间：
1991-11-01
影响因子：
15.3
通讯作者：
RAMMENSEE, HG
中科院分区：
文献类型：
--
作者：
ROTZSCHKE, O;FALK, K;FAATH, S;RAMMENSEE, HG
T细胞对外源性主要组织相容性复合体（MHC）抗原的强烈反应，通常被称为“同种异体反应性”，不仅是临床器官移植的麻烦，也是免疫学家的一个困惑问题。通过利用最近的技术发展，同种异体反应性T细胞名义上针对单个MHC I类分子中的突变被发现分为几个主要类别。一种是识别依赖于一个特定MHC等位基因的肽，另一种是识别由几个MHC等位基因支持的肽，第三种是识别独立于MHC等位基因出现的肽。在第四类中，任何广泛的肽与MHC的结合似乎是足够的。此外，存在根本不能检测到肽参与的T细胞。即使在这些类别中，T细胞的异质性也是相当大的：在分析的16种Kb反应性T细胞中，发现了15种不同的反应模式。
The strong reaction of T cells against foreign major histocompatibility complex (MHC) antigens, commonly termed "alloreactivity", is not only a nuisance for clinical organ transplantation; it also remains a puzzling question for immunologists. By making use of recent technical developments, alloreactive T cells nominally directed against a mutation in a single MHC class I molecule were found to fall into several major categories. One is recognizing peptides whose occurrence is dependent on one particular MHC allele, another is recognizing peptides supported by several MHC alleles, and a third is recognizing peptides occurring independently of MHC alleles. In a fourth category, the binding to MHC of any of a broad range of peptides appears sufficient. In addition, there are T cells for which no peptide involvement could be detected at all. Even within these categories, the heterogeneity of T cells is considerable: among 16 Kb-reactive T cells analyzed, 15 different modes of reactions were found.
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DOI：
10.1084/jem.174.2.425
发表时间：
1991-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Falk K;Rötzschke O;Deres K;Metzger J;Jung G;Rammensee HG
通讯作者：
Rammensee HG
DOI：
10.1084/jem.162.6.1745
发表时间：
1985-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ljunggren HG;Kärre K
通讯作者：
Kärre K
影响因子：
64.8
作者：
FALK, K;ROTZSCHKE, O;RAMMENSEE, HG
通讯作者：
RAMMENSEE, HG
影响因子：
15.3
作者：
GROVES, ES;SINGER, A
通讯作者：
SINGER, A
影响因子：
64.8
作者：
HEATH, WR;HURD, ME;SHERMAN, LA
通讯作者：
SHERMAN, LA