Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions
Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions
复制标题
通过获得不同的顺式调控区域，三个果蝇基因的不同发育功能的进化
作者：
Xuelin Li;M. Noll
IT is generally accepted that the specific function of a gene depends on its coding sequence. The three paired-box and homeobox genes paired (prd), gooseberry (gsb) and gooseberry neuro (gsbn) have distinct developmental functions in Drosophila embryogenesis1–5. During the syncytial blastoderm stage, the pair-rule gene prd 4,6 activates segment-polarity genes, such as gsb 7, wingless (wg)9 and engrailed (en), in segmentally repeated stripes8. After germ-band extension, gsb maintains the expression of wg, which in turn specifies the denticle pattern by repressing a default state of ubiquitous denticle formation in the ventral epidermis9. In addition, gsb activates gsbn 5, which is expressed mainly in the central nervous system2,3, suggesting that gsbn is involved in neural development. Here we show that, despite the functional difference and the considerably diverged coding sequence of these genes, their proteins have conserved the same function. The finding that the essential difference between genes may reside in their cis-regulatory regions exemplifies an important evolutionary mechanism of how function diversifies after gene duplication.
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影响因子：
10.5
作者：
Morrissey,D;Askew,D;Raj,L;Weir,M
通讯作者：
Weir,M
影响因子：
10.5
作者：
N. Patel;B. Schafer;C. Goodman;R. Holmgren
通讯作者：
N. Patel;B. Schafer;C. Goodman;R. Holmgren
影响因子：
10.5
作者：
DINARDO, S;OFARRELL, PH
通讯作者：
OFARRELL, PH
影响因子：
56.9
作者：
JOYNER, AL;HERRUP, K;ROSSANT, J
通讯作者：
ROSSANT, J