Comparative genomics of odorant binding proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus.
Comparative genomics of odorant binding proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus.
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DOI：
10.1093/gbe/evs131
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发表时间：
2013
影响因子：
3.3
通讯作者：
Offmann B
中科院分区：
文献类型：
--
作者：
Manoharan M;Ng Fuk Chong M;Vaïtinadapoulé A;Frumence E;Sowdhamini R;Offmann B
世界上每年约有100万人死于蚊子传播的疾病，了解蚊子通过嗅觉识别宿主的机制至关重要。气味结合蛋白（OBP）在蚊虫嗅觉初级分子事件中的作用正成为该领域生物学研究的重要热点。在这里，我们提出了一个全面的比较基因组学研究的OBP在三个疾病传播的蚊子种冈比亚按蚊，埃及伊蚊，致倦库蚊开始在这三个基因组中的110个新的OBP的鉴定。我们的特点是它们的基因组分布和直系和系统发育关系。观察到的伊蚊和库蚊基因组的多样性和扩张表明，OBP基因家族获得的功能多样性，同时对这两个物种的功能限制。具有独特特征的序列已被表征，例如蚊子基因组中的“双结构域OBP”（以前称为非典型OBP）和“MinusC OBP”。因此，在这项工作中，广泛的比较基因组学的特点，提供了有用的初步见解OBP在蚊子嗅觉系统的分子适应的作用，并可能提供更多的线索，为确定潜在的目标，昆虫驱避剂和引诱剂。
About 1 million people in the world die each year from diseases spread by mosquitoes, and understanding the mechanism of host identification by the mosquitoes through olfaction is at stake. The role of odorant binding proteins (OBPs) in the primary molecular events of olfaction in mosquitoes is becoming an important focus of biological research in this area. Here, we present a comprehensive comparative genomics study of OBPs in the three disease-transmitting mosquito species Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus starting with the identification of 110 new OBPs in these three genomes. We have characterized their genomic distribution and orthologous and phylogenetic relationships. The diversity and expansion observed with respect to the Aedes and Culex genomes suggests that the OBP gene family acquired functional diversity concurrently with functional constraints posed on these two species. Sequences with unique features have been characterized such as the “two-domain OBPs” (previously known as Atypical OBPs) and “MinusC OBPs” in mosquito genomes. The extensive comparative genomics featured in this work hence provides useful primary insights into the role of OBPs in the molecular adaptations of mosquito olfactory system and could provide more clues for the identification of potential targets for insect repellants and attractants.
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影响因子：
2.2
作者：
Li, ZX;Pickett, JA;Zhou, JJ
通讯作者：
Zhou, JJ
影响因子：
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作者：
Hekmat-Scafe, DS;Scafe, CR;Tanouye, MA
通讯作者：
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影响因子：
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作者：
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通讯作者：
Gibson, TJ
影响因子：
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作者：
Ishida, Y;Chen, AM;Leal, WS
通讯作者：
Leal, WS
影响因子：
3.4
作者：
Kalume, DE;Okulate, M;Pandey, A
通讯作者：
Pandey, A