Health Benefits of Quercetin in Age-Related Diseases.
Health Benefits of Quercetin in Age-Related Diseases.
复制标题
DOI：
10.3390/molecules27082498
复制
发表时间：
2022-04-13
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
多酚是已知的一类植物化学物质，主要由酚环组成。这些是存在于各种水果和蔬菜中的植物产品。这些次生代谢物在植物免受环境和生物胁迫时起着保护作用。当作为人类饮食食用时，它们也被认为可以预防各种与年龄相关的疾病。众所周知，多酚具有抗氧化特性，并防止氧化应激。这项文献调查是使用PubMed、Science Direct和Springer等数据库进行的。本综述选择了过去10-12年的研究文章，基于其与该主题的相关性。所选文章主要集中在槲皮素及其对健康的益处。本文着重介绍了一种黄酮类化合物--槲皮素的主要功能。槲皮素是广泛存在的多酚之一，在自然界中大量存在。它普遍存在于不同的植物产品中。众所周知，洋葱含有最高含量的槲皮素。这种植物化合物具有抗氧化特性，被认为具有防止衰老的功能。已知它以自由形式和共轭形式存在。槲皮素具有抗氧化、抗炎、抗增殖、抗癌、抗糖尿病和抗病毒等特性。这种分子是亲脂的，可以很容易地穿过血脑屏障，从而保护自己免受神经退行性疾病的侵袭。各种体内和体外研究已经证明了槲皮素的作用，在这里，作为治疗神经退行性变、糖尿病、癌症和炎症的药物进行了详细的综述。研究证明，槲皮素在预防老年性疾病方面起着至关重要的作用。Quercetin是一种有效的抗氧化剂，目前正被用于各种药物。在其他各种疾病中，可以进一步探讨槲皮素的特性。槲皮素的纳米制剂和脂质体制剂可以用于治疗其他与年龄相关的疾病。
Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10–12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.
登录
查看更多内容
影响因子：
5
作者：
Guran, Mumtaz;Sanliturk, Gizem;Yalcin, A. Suha
通讯作者：
Yalcin, A. Suha
影响因子：
1.6
作者：
Chen T;Zhang X;Zhu G;Liu H;Chen J;Wang Y;He X
通讯作者：
He X
影响因子：
4.1
作者：
Amanzadeh, Elnaz;Esmaeili, Abolghasem;Nourbakhshnia, Maryam
通讯作者：
Nourbakhshnia, Maryam
影响因子：
3.9
作者：
Chen, Weijun;Zou, Mingming;Liu, Donghong
通讯作者：
Liu, Donghong
影响因子：
4.2
作者：
Hashemzaei M;Delarami Far A;Yari A;Heravi RE;Tabrizian K;Taghdisi SM;Sadegh SE;Tsarouhas K;Kouretas D;Tzanakakis G;Nikitovic D;Anisimov NY;Spandidos DA;Tsatsakis AM;Rezaee R
通讯作者：
Rezaee R