Plasmids do not consistently stabilize cooperation across bacteria but may promote broad pathogen host-range.
Plasmids do not consistently stabilize cooperation across bacteria but may promote broad pathogen host-range.
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DOI：
10.1038/s41559-021-01573-2
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发表时间：
2021-12
影响因子：
16.8
通讯作者：
Ghoul M
中科院分区：
文献类型：
--
作者：
Dewar AE;Thomas JL;Scott TW;Wild G;Griffin AS;West SA;Ghoul M
通过质粒的水平基因转移可能有利于细菌之间的合作，因为合作基因的转移会把不合作的骗子变成合作者。这一假说得到了理论、基因组和实验分析的支持。相比之下，我们在这里通过对51个不同物种的比较分析表明，细胞外蛋白的基因很可能作为合作的“公共产品”，但并不更有可能携带：(I)与染色体相比的质粒；或(Ii)以更高速率转移的质粒。我们的结果得到了理论模型的支持，该模型表明，虽然水平基因转移可以帮助合作基因最初入侵种群，但它对合作的长期维持影响较小。相反，我们发现，在宿主范围广泛的病原菌中，当细胞外蛋白的基因编码致病毒力特征时，它们更有可能位于质粒上。
Horizontal gene transfer via plasmids could favour cooperation in bacteria, because transfer of a cooperative gene turns non-cooperative cheats into cooperators. This hypothesis has received support from theoretical, genomic and experimental analyses. In contrast, we show here, with a comparative analysis across 51 diverse species, that genes for extracellular proteins, which are likely to act as cooperative ‘public goods’, were not more likely to be carried on either: (i) plasmids compared to chromosomes; or (ii) plasmids that transfer at higher rates. Our results were supported by theoretical modelling which showed that while horizontal gene transfer can help cooperative genes initially invade a population, it has less influence on the longer-term maintenance of cooperation. Instead, we found that genes for extracellular proteins were more likely to be on plasmids when they coded for pathogenic virulence traits, in pathogenic bacteria with a broad host-range.
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