Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects.
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects.
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DOI：
10.3390/diagnostics7030045
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发表时间：
2017-07-26
期刊：
影响因子：
--
通讯作者：
Guy OJ
中科院分区：
文献类型：
--
作者：
Forsyth R;Devadoss A;Guy OJ
自从十多年前发现二维（2D）碳材料石墨烯以来，石墨烯基场效应晶体管（G-FET）的开发已成为一个广泛研究的领域，特别是用于即时医疗生物医学应用。G-FET作为下一代生物电子器件特别有吸引力，因为它们的大规模可扩展性和技术制造的低成本。此外，G-FET提供了完成无标记、快速和高灵敏度分析的潜力，并具有高样品通量。这些特性，再加上集成到便携式仪器的潜力，有助于G-FET适用于现场护理诊断。本文综述了近年来G-FET传感器领域的最新进展，G-FET传感器基于生物亲和性作用，将生物受体与目标分析物之间的结合事件转换为G-FET表面的电信号。准确可靠地识别和定量这些目标分析物对于诊断许多疾病至关重要，因此精心设计G-FET至关重要。考虑到传感器平台的一些限制，例如Debye-Hükel筛选和设备表面积，是开发用于临床环境的改进生物电子学的基础。这篇评论强调了一些努力，面对这些限制，以使G-FET的生物医学应用的发展。
Since the discovery of the two-dimensional (2D) carbon material, graphene, just over a decade ago, the development of graphene-based field effect transistors (G-FETs) has become a widely researched area, particularly for use in point-of-care biomedical applications. G-FETs are particularly attractive as next generation bioelectronics due to their mass-scalability and low cost of the technology’s manufacture. Furthermore, G-FETs offer the potential to complete label-free, rapid, and highly sensitive analysis coupled with a high sample throughput. These properties, coupled with the potential for integration into portable instrumentation, contribute to G-FETs’ suitability for point-of-care diagnostics. This review focuses on elucidating the recent developments in the field of G-FET sensors that act on a bioaffinity basis, whereby a binding event between a bioreceptor and the target analyte is transduced into an electrical signal at the G-FET surface. Recognizing and quantifying these target analytes accurately and reliably is essential in diagnosing many diseases, therefore it is vital to design the G-FET with care. Taking into account some limitations of the sensor platform, such as Debye–Hükel screening and device surface area, is fundamental in developing improved bioelectronics for applications in the clinical setting. This review highlights some efforts undertaken in facing these limitations in order to bring G-FET development for biomedical applications forward.
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影响因子：
10.9
作者：
Deokar, G.;Avila, J.;Vignaud, D.
通讯作者：
Vignaud, D.
影响因子：
13.3
作者：
Kim, Duck-Jin;Park, Hae-Chul;Lee, Nae-Eung
通讯作者：
Lee, Nae-Eung
影响因子：
44.1
作者：
Das Sarma, S.;Adam, Shaffique;Rossi, Enrico
通讯作者：
Rossi, Enrico
影响因子：
2.1
作者：
Bolotin, K. I.;Sikes, K. J.;Stormer, H. L.
通讯作者：
Stormer, H. L.
DOI：
10.1073/pnas.1603753113
发表时间：
2016-06-28
影响因子：
11.1
作者：
Hwang, Michael T.;Landon, Preston B.;Lal, Ratnesh
通讯作者：
Lal, Ratnesh