Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.
复制标题
DOI：
10.1146/annurev-cellbio-100109-104037
复制
发表时间：
2010
影响因子：
11.3
通讯作者：
Fridolfsson HN
中科院分区：
文献类型：
--
作者：
Starr DA;Fridolfsson HN
核膜将细胞骨架与细胞核的结构成分连接起来。它的功能是协调核迁移和锚定，组织染色质，并帮助减数分裂染色体配对。由细胞骨架产生的力通过由SUN（Sad 1和NES-84）和KASH（Klarsicht、ANC-1和Syne/Nesprin同源物）蛋白组成的核被膜桥穿过核膜转移到核纤层。一些KASH-SUN组合将微管、中心体、肌动蛋白丝或中间丝连接到核的表面。其他组合用于细胞周期控制、核输入或凋亡。细胞骨架和细胞核之间的相互作用也影响整体细胞骨架组织。SUN和KASH蛋白通过基因筛选在模式生物中错误定位的细胞核来鉴定。SUN或KASH蛋白的敲除会破坏小鼠的神经和肌肉发育。SUN和KASH蛋白的缺陷与人类疾病有关，包括肌肉萎缩症、共济失调、早衰症、无脑畸形和癌症。
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It functions to coordinate nuclear migration and anchorage, organize chromatin, and aid meiotic chromosome pairing. Forces generated by the cytoskeleton are transferred across the nuclear envelope to the nuclear lamina through a nuclear-envelope bridge consisting of SUN (Sad1 and UNC-84) and KASH (Klarsicht, ANC-1 and Syne/Nesprin homology) proteins. Some KASH-SUN combinations connect microtubules, centrosomes, actin filaments, or intermediate filaments to the surface of the nucleus. Other combinations are used in cell cycle control, nuclear import, or apoptosis. Interactions between the cytoskeleton and the nucleus also affect global cytoskeleton organization. SUN and KASH proteins were identified through genetic screens for mispositioned nuclei in model organisms. Knockouts of SUN or KASH proteins disrupt neurological and muscular development in mice. Defects in SUN and KASH proteins have been linked to human diseases including muscular dystrophy, ataxia, progeria, lissencephaly, and cancer.
登录
查看更多内容
影响因子：
64.5
作者：
Chikashige, Y;Tsutsumi, C;Hiraoka, Y
通讯作者：
Hiraoka, Y
影响因子：
64.5
作者：
Conrad, Michael N.;Lee, Chih-Ying;Dresser, Michael E.
通讯作者：
Dresser, Michael E.
DOI：
10.1073/pnas.0402727101
发表时间：
2004-06-01
影响因子：
11.1
作者：
Braunagel, SC;Williamson, ST;Summers, MD
通讯作者：
Summers, MD
影响因子：
3.3
作者：
Fischer, JA;Acosta, S;Hook, J
通讯作者：
Hook, J
影响因子：
3.5
作者：
Broers, JLV;Peeters, EAG;Ramaekers, FCS
通讯作者：
Ramaekers, FCS