AMYQ: An index to standardize quantitative amyloid load across PET tracers.
AMYQ: An index to standardize quantitative amyloid load across PET tracers.
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AMYQ：一种标准化PET示踪剂中定量淀粉样蛋白负荷的指数。
DOI：
10.1002/alz.12317
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Australian Imaging, Biomarkers and Lifestyle Research Group
中科院分区：
文献类型：
--
作者：
Pegueroles J;Montal V;Bejanin A;Vilaplana E;Aranha M;Santos-Santos MA;Alcolea D;Carrió I;Camacho V;Blesa R;Lleó A;Fortea J;Alzheimer Disease Neuroimaging Initiative;Australian Imaging, Biomarkers and Lifestyle Research Group
正电子发射断层扫描（PET）淀粉样蛋白定量方法需要磁共振成像（MRI）进行空间配准和先验参考区域来缩放图像。此外，不同的示踪剂具有不同的阳性阈值。我们提出了AMYQ指数，一种新的衡量淀粉样蛋白负荷的方法，以克服这些局限性。我们选择了来自ADNI和Australian Imaging，Biomarker & Lifestyle Flagship Study of Ageing（Aibl）的18 F ‐淀粉样蛋白扫描以及相应的T1‐MRI。一个子集也有神经病理学数据。对PET图像进行归一化，并基于自适应模板计算AMYQ。我们比较了AMYQ与Centiloid量表在临床和神经病理诊断性能方面的差异。AMYQ与淀粉样蛋白神经病理学负荷相关，并具有极好的诊断性能，以区分对照组与阿尔茨海默病（AD）患者（曲线下面积[AUC] = 0.86）。当使用不同的Centiloid截止值时，AMYQ与Centiloid量表（组内相关系数[ICC] = 0.88）高度一致，AUC在0.94和0.99之间，以区分PET阳性。AMYQ是一种新的MRI独立指数，用于标准化和量化示踪剂之间的淀粉样蛋白负荷。
Positron emission tomography (PET) amyloid quantification methods require magnetic resonance imaging (MRI) for spatial registration and a priori reference region to scale the images. Furthermore, different tracers have distinct thresholds for positivity. We propose the AMYQ index, a new measure of amyloid burden, to overcome these limitations. We selected 18F‐amyloid scans from ADNI and Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) with the corresponding T1‐MRI. A subset also had neuropathological data. PET images were normalized, and the AMYQ was calculated based on an adaptive template. We compared AMYQ with the Centiloid scale on clinical and neuropathological diagnostic performance. AMYQ was related with amyloid neuropathological burden and had excellent diagnostic performance to discriminate controls from patients with Alzheimer's disease (AD) (area under the curve [AUC] = 0.86). AMYQ had a high agreement with the Centiloid scale (intraclass correlation coefficient [ICC] = 0.88) and AUC between 0.94 and 0.99 to discriminate PET positivity when using different Centiloid cutoffs. AMYQ is a new MRI‐independent index for standardizing and quantifying amyloid load across tracers.
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DOI：
10.1093/brain/aww160
发表时间：
2016-09
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Leuzy A;Chiotis K;Hasselbalch SG;Rinne JO;de Mendonça A;Otto M;Lleó A;Castelo-Branco M;Santana I;Johansson J;Anderl-Straub S;von Arnim CA;Beer A;Blesa R;Fortea J;Herukka SK;Portelius E;Pannee J;Zetterberg H;Blennow K;Nordberg A
通讯作者：
Nordberg A
DOI：
10.1007/s00259-014-2753-3
发表时间：
2014-07
影响因子：
9.1
作者：
Landau, S. M.;Thomas, B. A.;Thurfjell, L.;Schmidt, M.;Margolin, R.;Mintun, M.;Pontecorvo, M.;Baker, S. L.;Jagust, W. J.
通讯作者：
Jagust, W. J.
DOI：
10.1007/s00259-015-3156-9
发表时间：
2016-01-01
影响因子：
9.1
作者：
Adamczuk, Katarzyna;Schaeverbeke, Jolien;Vandenberghe, Rik
通讯作者：
Vandenberghe, Rik
影响因子：
9.3
作者：
Chiao, Ping;Bedell, Barry J.;Koeppe, Robert
通讯作者：
Koeppe, Robert
影响因子：
5.7
作者：
Edison, P.;Carter, S. F.;Hinz, R.
通讯作者：
Hinz, R.