The sperm centrioles.
The sperm centrioles.
复制标题
DOI：
10.1016/j.mce.2020.110987
复制
发表时间：
2020-12-01
影响因子：
4.1
通讯作者：
Fishman EL
中科院分区：
文献类型：
--
作者：
Avidor-Reiss T;Carr A;Fishman EL
中心粒是真核生物的亚细胞结构，产生并调节大量的亚细胞骨架超结构。它们形成中心体和纤毛，调节新中心粒的形成，将纤毛固定在细胞上，并调节纤毛功能。这些基本的中心粒功能在精原干细胞分化为精子的扩增过程中以及最终在受精后精子与卵子融合时在精细胞中执行。然而，精子中心粒表现出许多在其他细胞类型中不常见的独特特征，包括结构重塑，中心粒-鞭毛过渡区迁移和减数分裂期间的细胞膜结合。在这里，我们讨论了精子中心粒的五个作用：协调早期生精细胞分裂，形成精子鞭毛，连接精子头部和尾部，控制精子尾部跳动，并组织受精后受精卵的细胞骨架。我们提出了历史性的发现，中心粒作为精子因子，启动胚胎发生，和最近的遗传研究在人类和其他哺乳动物评估目前的证据，精子中心粒的五个功能。我们还研究了不同精子中心粒功能与不同临床表型之间的关系。中心粒是精子的重要组成部分，具有显着的功能多样性和专业化，这将需要广泛和深入的未来研究。
Centrioles are eukaryotic subcellular structures that produce and regulate massive subcellular cytoskeleton superstructures. They form centrosomes and cilia, regulate new centriole formation, secure cilia to the cell, and regulate cilia function. These basic centriolar functions are executed in sperm cells during their amplification from spermatogonial stem cells during their differentiation to spermatozoa, and finally, after fertilization, when the sperm fuses with the egg. However, sperm centrioles exhibit many unique characteristics not commonly observed in other cell types, including structural remodeling, centriole-flagellum transition zone migration, and cell membrane association during meiosis. Here, we discuss five roles of sperm centrioles: orchestrating early spermatogenic cell divisions, forming the spermatozoon flagella, linking the spermatozoon head and tail, controlling sperm tail beating, and organizing the cytoskeleton of the zygote post-fertilization. We present the historic discovery of the centriole as a sperm factor that initiates embryogenesis, and recent genetic studies in humans and other mammals evaluating the current evidence for the five functions of sperm centrioles. We also examine information connecting the various sperm centriole functions to distinct clinical phenotypes. The emerging picture is that centrioles are essential sperm components with remarkable functional diversity and specialization that will require extensive and in-depth future studies.
登录
查看更多内容
影响因子：
16.6
作者：
Bowler, Mathew;Kong, Dong;Loncarek, Jadranka
通讯作者：
Loncarek, Jadranka
影响因子：
1.5
作者：
Barbas, J. P.;Mascarenhas, R. D.
通讯作者：
Mascarenhas, R. D.
影响因子：
9.2
作者：
Basiri, Marcus L.;Ha, Andrew;Chadha, Abhishek;Clark, Nicole M.;Polyanovsky, Andrey;Cook, Boaz;Avidor-Reiss, Tomer
通讯作者：
Avidor-Reiss, Tomer
DOI：
10.1083/jcb.2.3.223
发表时间：
1956-01-01
期刊：
JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY
影响因子：
--
作者：
BURGOS, MH;FAWCETT, DW
通讯作者：
FAWCETT, DW
影响因子：
4.4
作者：
Aoto, H;Miyake, Y;Tajima, S
通讯作者：
Tajima, S