Maternal One-Carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review.
Maternal One-Carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review.
复制标题
DOI：
10.3390/genes12101634
复制
发表时间：
2021-10-17
期刊：
影响因子：
3.5
通讯作者：
Rousian M
中科院分区：
文献类型：
--
作者：
Rubini E;Baijens IMM;Horánszky A;Schoenmakers S;Sinclair KD;Zana M;Dinnyés A;Steegers-Theunissen RPM;Rousian M
围孕期的母体环境部分通过一碳代谢途径调节的表观遗传机制影响胎儿的生长和发育。在胚胎发育过程中，一碳代谢参与大脑发育和神经编程。一碳代谢紊乱会增加（i）胚胎神经管相关缺陷的短期风险和（ii）长期儿童行为、认知和自闭症谱系障碍。在这里，我们研究母体一碳代谢与胎儿和新生儿大脑生长发育之间的关联。数据库搜索结果有 26 篇文章符合纳入条件。母体维生素 B6、维生素 B12、同型半胱氨酸和胆碱与胎儿和/或新生儿头部生长无关。妊娠早期母体血浆叶酸在正常范围内（>17 nmol/L）与胎儿头部大小和头部生长增加相关，红细胞叶酸较高（1538-1813 nmol/L）与小脑生长增加相关，而叶酸缺乏（<7 nmol/L）与胎儿脑体积减少相关。孕前补充叶酸和特定的饮食模式（与增加 B 族维生素和降低同型半胱氨酸相关）会增加胎儿头部的大小。尽管妊娠早期母体叶酸似乎是胎儿大脑生长最独立的预测因子，但没有足够的数据证实母体叶酸与后代神经发育疾病风险之间的联系。
The maternal environment during the periconceptional period influences foetal growth and development, in part, via epigenetic mechanisms moderated by one-carbon metabolic pathways. During embryonic development, one-carbon metabolism is involved in brain development and neural programming. Derangements in one-carbon metabolism increase (i) the short-term risk of embryonic neural tube-related defects and (ii) long-term childhood behaviour, cognition, and autism spectrum disorders. Here we investigate the association between maternal one-carbon metabolism and foetal and neonatal brain growth and development. Database searching resulted in 26 articles eligible for inclusion. Maternal vitamin B6, vitamin B12, homocysteine, and choline were not associated with foetal and/or neonatal head growth. First-trimester maternal plasma folate within the normal range (>17 nmol/L) associated with increased foetal head size and head growth, and high erythrocyte folate (1538–1813 nmol/L) with increased cerebellar growth, whereas folate deficiency (<7 nmol/L) associated with a reduced foetal brain volume. Preconceptional folic acid supplement use and specific dietary patterns (associated with increased B vitamins and low homocysteine) increased foetal head size. Although early pregnancy maternal folate appears to be the most independent predictor of foetal brain growth, there is insufficient data to confirm the link between maternal folate and offspring risks for neurodevelopmental diseases.
登录
查看更多内容
影响因子：
3.7
作者：
Bonilla C;Lawlor DA;Taylor AE;Gunnell DJ;Ben-Shlomo Y;Ness AR;Timpson NJ;St Pourcain B;Ring SM;Emmett PM;Smith AD;Refsum H;Pennell CE;Brion MJ;Smith GD;Lewis SJ
通讯作者：
Lewis SJ
影响因子：
5.6
作者：
Clare CE;Pestinger V;Kwong WY;Tutt DAR;Xu J;Byrne HM;Barrett DA;Emes RD;Sinclair KD
通讯作者：
Sinclair KD
DOI：
10.1017/s0007114516004281
发表时间：
2019-09-01
期刊：
The British journal of nutrition
影响因子：
--
作者：
Catena, Andres;Martinez-Zaldivar, Cristina;Campoy, Cristina
通讯作者：
Campoy, Cristina
影响因子：
3.9
作者：
Elder, Lauren M.;Dawson, Geraldine;Munson, Jeff
通讯作者：
Munson, Jeff
影响因子：
2.5
作者：
Bulloch, Rhodi E.;Wall, Clare R.;McCowan, Lesley M. E.
通讯作者：
McCowan, Lesley M. E.