Rhythmic interactions between the mediodorsal thalamus and prefrontal cortex precede human visual perception.
Rhythmic interactions between the mediodorsal thalamus and prefrontal cortex precede human visual perception.
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DOI：
10.1038/s41467-022-31407-z
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发表时间：
2022-06-29
影响因子：
16.6
通讯作者：
Staudigl, Tobias
中科院分区：
文献类型：
--
作者：
Griffiths, Benjamin J.;Zaehle, Tino;Repplinger, Stefan;Schmitt, Friedhelm C.;Voges, Juergen;Hanslmayr, Simon;Staudigl, Tobias
丘脑不仅仅是一个简单的感觉中继站。高阶丘脑核团，例如内侧丘脑，对动物认知产生深远影响。然而，鉴于直接从人类丘脑进行记录的难度，我们对丘脑和丘脑皮质对人类认知的贡献几乎一无所知。为了解决这个问题，我们分析了 6 名患者完成视觉检测任务时同时记录的丘脑 iEEG 和全头 MEG（加上 12 名健康对照者的 MEG 记录）。我们观察到正在进行的内侧丘脑和前额叶低频活动的阶段可以预测知觉表现。然而，至关重要的是，丘脑内侧活动介导了前额叶对知觉表现的贡献。这些结果表明，丘脑皮质相互作用，而不仅仅是皮质活动，可以预测即将到来的知觉表现，更一般地说，强调了在理论皮质对人类认知的贡献时考虑丘脑的重要性。丘脑和皮质在感知背景下如何相互作用仍然很大程度上不清楚。在这里，作者表明，人类内侧丘脑和前额叶皮层的节律活动相互作用，以预测是否会看到接近阈值的视觉刺激，这与丘脑是一个简单中继的传统观点相矛盾。
The thalamus is much more than a simple sensory relay. High-order thalamic nuclei, such as the mediodorsal thalamus, exert a profound influence over animal cognition. However, given the difficulty of directly recording from the thalamus in humans, next-to-nothing is known about thalamic and thalamocortical contributions to human cognition. To address this, we analysed simultaneously-recorded thalamic iEEG and whole-head MEG in six patients (plus MEG recordings from twelve healthy controls) as they completed a visual detection task. We observed that the phase of both ongoing mediodorsal thalamic and prefrontal low-frequency activity was predictive of perceptual performance. Critically however, mediodorsal thalamic activity mediated prefrontal contributions to perceptual performance. These results suggest that it is thalamocortical interactions, rather than cortical activity alone, that is predictive of upcoming perceptual performance and, more generally, highlights the importance of accounting for the thalamus when theorising about cortical contributions to human cognition. How the thalamus and the cortex interact in the context of perception remains largely unclear. Here, the authors show that rhythmic activity in the human mediodorsal thalamus and prefrontal cortex interact to predict whether a near-threshold visual stimulus will be seen, contradicting the traditional view that the thalamus is a simple relay.
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影响因子：
16.6
作者：
Griffiths, Benjamin J.;Zaehle, Tino;Repplinger, Stefan;Schmitt, Friedhelm C.;Voges, Juergen;Hanslmayr, Simon;Staudigl, Tobias
通讯作者：
Staudigl, Tobias
影响因子：
5.3
作者：
Busch, Niko A.;Dubois, Julien;VanRullen, Rufin
通讯作者：
VanRullen, Rufin
影响因子：
14.5
作者：
Del Cul, A.;Dehaene, S.;Slachevsky, A.
通讯作者：
Slachevsky, A.
影响因子：
3.4
作者：
Benwell, Christopher S. Y.;Coldea, Andra;Thut, Gregor
通讯作者：
Thut, Gregor
影响因子：
2
作者：
Ciaramelli, Elisa;Leo, Fabrizio;Ladavas, Elisabetta
通讯作者：
Ladavas, Elisabetta