High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma.
High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma.
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DOI:
10.1038/sj.bjc.6690131
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发表时间:
1999-02
影响因子:
8.8
通讯作者:
中科院分区:
文献类型:
--
作者:
Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 μmol kg−1) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1–3 h with recoveries of 1.84– 1.96 μmol kg−1. Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes. © 1999 Cancer Research Campaign
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影响因子:
3.3
作者:
BIOLO, R;JORI, G;RODGERS, MAJ
通讯作者:
RODGERS, MAJ
影响因子:
3.3
作者:
ALLISON, BA;WATERFIELD, E;LEVY, JG
通讯作者:
LEVY, JG
影响因子:
3.3
作者:
Biolo, R;Jori, G;Rodgers, MAJ
通讯作者:
Rodgers, MAJ
影响因子:
8.8
作者:
CUOMO, V;JORI, G;RODGERS, MAJ
通讯作者:
RODGERS, MAJ
DOI:
10.1016/1011-1344(90)80008-l
发表时间:
1990-04-15
影响因子:
5.4
作者:
RICHTER, AM;CERRUTISOLA, S;LEVY, JG
通讯作者:
LEVY, JG