Chronic gestational stress leads to depressive-like behavior and compromises medial prefrontal cortex structure and function during the postpartum period.
Chronic gestational stress leads to depressive-like behavior and compromises medial prefrontal cortex structure and function during the postpartum period.
复制标题
DOI：
10.1371/journal.pone.0089912
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Albin-Brooks C
中科院分区：
文献类型：
--
作者：
Leuner B;Fredericks PJ;Nealer C;Albin-Brooks C
Postpartum depression, which affects approximately 15% of new mothers, is associated with impaired mother-infant interactions and deficits in cognitive function. Exposure to stress during pregnancy is a major risk factor for postpartum depression. However, little is known about the neural consequences of gestational stress. The medial prefrontal cortex (mPFC) is a brain region that has been linked to stress, cognition, maternal care, and mood disorders including postpartum depression. Here we examined the effects of chronic gestational stress on mPFC function and whether these effects might be linked to structural modifications in the mPFC. We found that in postpartum rats, chronic gestational stress resulted in maternal care deficits, increased depressive-like behavior, and impaired performance on an attentional set shifting task that relies on the mPFC. Furthermore, exposure to chronic stress during pregnancy reduced dendritic spine density on mPFC pyramidal neurons and altered spine morphology. Taken together, these findings suggest that pregnancy stress may contribute to postpartum mental illness and its associated symptoms by compromising structural plasticity in the mPFC.
登录
查看更多内容
影响因子：
3.3
作者：
Atkinson, Leslie;Leung, Eman;Kerr, Sheila
通讯作者：
Kerr, Sheila
影响因子：
2.7
作者：
Darnaudéry, M;Dutriez, I;Maccari, S
通讯作者：
Maccari, S
影响因子：
10.6
作者：
Champagne, Frances A.;Meaney, Michael J.
通讯作者：
Meaney, Michael J.
影响因子：
1.5
作者：
Brand, Sarah R.;Brennan, Patricia A.
通讯作者：
Brennan, Patricia A.
影响因子：
2.9
作者：
Febo, Marcelo;Felix-Ortiz, Ada C.;Johnson, Tehya R.
通讯作者：
Johnson, Tehya R.