Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome.
Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome.
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DOI：
10.1016/j.neuroimage.2009.05.078
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发表时间：
2009-09
期刊：
影响因子：
5.7
通讯作者：
Mayer, Emeran A.
中科院分区：
文献类型：
--
作者：
Labus, Jennifer S.;Naliboff, Bruce D.;Berman, Steve M.;Suyenobu, Brandall;Vianna, Eduardo P.;Tillisch, Kirsten;Mayer, Emeran A.
肠易激综合征(IBS)患者对内脏刺激的不适和痛阈值降低，对胃肠道感觉、症状以及这些内脏感觉和症状发生的背景高度警惕。先前的研究表明，在重复暴露于实验性直肠刺激12个月后，内脏高敏感度恢复正常，这与与注意力和唤醒相关的皮质功能区域的减少有关。在这些功能分析的基础上，对12名IBS患者(男性=4名)的[150]水正电子发射断层扫描(PET)数据进行了多变量功能和有效连接性分析，这些患者在一年的时间里参加了4次涉及直肠气囊扩张的内脏感觉测试之前和之后的PET研究。首先，行为偏最小二乘法被用来测试在重复应用厌恶的直肠刺激后观察到的与降低的主观评分相关的网络。接下来，结构方程模型框架内的路径分析检验了这一假设，即对重复的内脏刺激的知觉习惯化部分是由于随着时间的推移，对威胁的选择性注意网络内的连接性降低所致。在期望和膨胀过程中，两个独立的知觉相关网络被不同地参与，这些网络由相互感觉、注意和唤醒区域组成。此外，注意网络的有效连通性以及杏仁核调制影响的变化表明，与重复刺激传递相关的知觉习惯化导致注意回路自上而下调制的增加，以及杏仁核对注意机制的干扰减少。
Patients with irritable bowel syndrome (IBS) show decreased discomfort and pain thresholds to visceral stimuli, as well hypervigilance to gastrointestinal sensations, symptoms, and the context in which these visceral sensations and symptoms occur. Previous research demonstrated normalization of visceral hypersensitivity following repeated exposure to experimental rectal stimuli over a 12 month period that was associated with reduction in cortical regions functionally associated with attention and arousal. Building upon these functional analyses, multivariate functional and effective connectivity analyses were applied to [15O] water positron emission tomography (PET) data from 12 IBS patients (male=4) participating in a PET study before and after 4 visceral sensory testing sessions involving rectal balloon distensions over a 1 year period. First, behavioral partial least squares was applied to test for networks related to reduced subjective ratings observed following repeated application of an aversive rectal stimulus. Next, path analysis within a structural equation modeling framework tested the hypothesis that perceptual habituation to the repeated visceral stimuli resulted in part from the reduced connectivity within a selective attention to threat network over time. Two independent, perception-related networks comprised of interoceptive, attentional and arousal regions were engaged differentially during expectation and distension. In addition, changes in the effective connectivity of an attentional network as well as modulatory amygdala influence suggested that perceptual habituation associated with repeated stimulus delivery results both in an increase in top down modulation of attentional circuits, as well as in a reduction of amygdala-related interference with attentional mechanisms.
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影响因子：
14.5
作者：
Bantick, SJ;Wise, RG;Tracey, I
通讯作者：
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DOI：
10.1152/ajpregu.00065.2006
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