Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid.
Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid.
复制标题
DOI：
10.3390/ijerph8062533
复制
发表时间：
2011-06
影响因子：
--
通讯作者：
Owoeye O
中科院分区：
文献类型：
--
作者：
Farombi EO;Owoeye O
最近，相当多的注意力集中在抑制、逆转或延缓氧化和炎症过程引起的疾病的膳食和药用植物化学物质上。苦杏仁是一种多年生草本植物，属于菊科。这种植物的提取物已被用于各种民间药物中，作为治疗蠕虫、原生动物和细菌感染的药物，这些说法得到了科学的支持。从苦杏仁中提取并分离出了皂苷、生物碱、萜烯、类固醇、香豆素、黄酮类、酚酸、木脂素、山酮、蒽醌、多肽和倍半萜等植物化学物质。这些化合物引起各种生物效应，包括癌症化学预防。Garcinia kola （Guttiferae）种子，被称为“苦kola”，在非洲民族医学和传统好客中发挥着重要作用。它在当地用于治疗感冒、支气管炎、细菌和病毒感染以及肝脏疾病等疾病。许多有用的植物化学物质已经从藤黄种子中分离出来，其中最突出的是藤黄生物类黄酮混合物，称为kolaviron。它具有明确的结构和一系列的生物活性，包括抗氧化、抗糖尿病、抗基因毒性和保护肝脏的特性。苦杏仁和藤黄类化合物具有清除自由基、诱导解毒、抑制应激反应蛋白和干扰转录因子DNA结合活性等化学预防作用。
Recently, considerable attention has been focused on dietary and medicinal phytochemicals that inhibit, reverse or retard diseases caused by oxidative and inflammatory processes. Vernonia amygdalina is a perennial herb belonging to the Asteraceae family. Extracts of the plant have been used in various folk medicines as remedies against helminthic, protozoal and bacterial infections with scientific support for these claims. Phytochemicals such as saponins and alkaloids, terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, edotides and sesquiterpenes have been extracted and isolated from Vernonia amygdalina. These compounds elicit various biological effects including cancer chemoprevention. Garcinia kola (Guttiferae) seed, known as “bitter kola”, plays an important role in African ethnomedicine and traditional hospitality. It is used locally to treat illnesses like colds, bronchitis, bacterial and viral infections and liver diseases. A number of useful phytochemicals have been isolated from the seed and the most prominent of them is the Garcinia bioflavonoids mixture called kolaviron. It has well-defined structure and an array of biological activities including antioxidant, antidiabetic, antigenotoxic and hepatoprotective properties. The chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoids have been attributed to their abilities to scavenge free radicals, induce detoxification, inhibit stress response proteins and interfere with DNA binding activities of some transcription factors.
登录
查看更多内容
DOI：
10.1111/j.0305-1870.2005.04248.x
发表时间：
2005-08-01
影响因子：
2.9
作者：
Farombi, EO;Nwaokeafor, IA
通讯作者：
Nwaokeafor, IA
影响因子：
2.6
作者：
Alawa, CBI;Adamu, AM;Bowman, DD
通讯作者：
Bowman, DD
影响因子：
3.4
作者：
Awe, SO;Makinde, JM;Olajide, OA
通讯作者：
Olajide, OA
DOI：
10.1039/p19780000532
发表时间：
1978-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
影响因子：
--
作者：
COTTERILL, PJ;SCHEINMANN, F;STENHOUSE, IA
通讯作者：
STENHOUSE, IA
影响因子：
--
作者：
Adesanoye, Omolola A.;Farombi, Ebenezer O.
通讯作者：
Farombi, Ebenezer O.