Increased efficiency of brain connectivity networks in veterans with suicide attempts.
Increased efficiency of brain connectivity networks in veterans with suicide attempts.
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DOI：
10.1016/j.nicl.2018.04.021
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Yurgelun-Todd D
中科院分区：
文献类型：
--
作者：
Hwang J;Legarreta M;Bueler CE;DiMuzio J;McGlade E;Lyoo IK;Yurgelun-Todd D
自杀是美国退伍军人和平民的公共卫生问题。先前的研究表明，神经生物学因素与自杀有关。然而，关于神经成像与自杀风险的相关性的研究一直很有限。这项研究应用复杂加权网络分析来表征有自杀行为的退伍军人脑白质中的神经连接。28名无自杀行为(NS)的退伍军人，29名仅有自杀意念史(SI)的退伍军人和23名有自杀未遂(SA)的退伍军人接受了扩散张量脑成像、哥伦比亚自杀严重程度评定量表和Barratt冲动量表(BIS)的检查。使用全脑束成像技术绘制了82个分割的大脑区域之间的结构连接网络。计算了网络拓扑的全局度量和节点度量。SA具有更短的特征路径长度、更高的全局效率和全球网络指标的平均加权程度(p <； 0.024)。SA具有比NS和SI更多的中枢节点。左侧后扣带回皮质在SA中的加权程度明显高于其他区域(p <； 0.0003)。BIS的非计划子量表与SA内左侧PCC的加权程度相关。在丰富的俱乐部连接中，SA的本地连接高于其他俱乐部(p = 0.001)。有自杀未遂的退伍军人改变了白质中的连接网络特征。这些发现可能是自杀未遂个体的独特神经生物学标志。在有自杀企图的退伍军人中，左侧PCC的强连通性可能与冲动有关。与仅有自杀意念的退伍军人相比，有自杀未遂史的退伍军人可能改变了白质中的连接网络，这可能是与早期白质成熟变化相关的神经生物学标志。有自杀未遂史的受试者中，后扣带回的过度连接可能与自杀行为的冲动有关。
Suicide is a public health concern for United States veterans and civilians. Prior research has shown neurobiological factors in suicide. However, studies of neuroimaging correlates of suicide risk have been limited. This study applied complex weighted network analyses to characterize the neural connectivity in white matter in veterans with suicide behavior. Twenty-eight veterans without suicide behavior (NS), 29 with a history of suicidal ideation only (SI), and 23 with prior suicide attempt (SA) completed diffusion tensor brain imaging, the Columbia Suicide Severity Rating Scale and Barratt Impulsiveness Scale (BIS). Structural connectivity networks among 82 parcellated brain regions were produced using whole-brain tractography. Global and nodal metrics of network topology have been calculated. SA had shorter characteristic path length and greater global efficiency and mean weighted degree of global network metrics (p < 0.024). SA had more hub nodes than NS and SI. The left posterior cingulate cortex (PCC) showed significantly greater weighted degree in SA relative to others (p < 0.0003). Nonplanning subscale of BIS correlated with the weighted degrees of the left PCC within SA. In rich club connectivity, SA had higher local connections than others (p = 0.001). Veterans with prior suicide attempt had altered connectivity networks characteristics in the white matter. These findings may be distinctive neurobiological markers for individuals with suicide attempt. Strong connectivity in the left PCC may be implicated in impulsivity in veterans with suicide attempt. Veterans with a history of suicide attempt may have altered connectivity networks in the white matter, relative to veterans with suicide ideation only, which may be neurobiological markers related to the white matter maturation changes in the earlier ages. Hyperconnected posterior cingulate cortex in the subjects with a history of suicide attempt may be associated with impulsivity of suicide behavior.
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影响因子：
3.2
作者：
Cox, BJ;Enns, MW;Clara, IP
通讯作者：
Clara, IP
影响因子：
5.7
作者：
Giorgio, Antonio;Santelli, Luca;Tomassini, Valentina;Bosnell, Rose;Smith, Steve;De Stefano, Nicola;Johansen-Berg, Heidi
通讯作者：
Johansen-Berg, Heidi
DOI：
10.1146/annurev-clinpsy-040510-143934
发表时间：
2011-01-01
影响因子：
18.4
作者：
Bullmore, Edward T.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.
影响因子：
6.6
作者：
Chase HW;Segreti AM;Keller TA;Cherkassky VL;Just MA;Pan LA;Brent DA
通讯作者：
Brent DA
影响因子：
2.9
作者：
Bijttebier S;Caeyenberghs K;van den Ameele H;Achten E;Rujescu D;Titeca K;van Heeringen C
通讯作者：
van Heeringen C